2,6-dichlorobenzyloxyamine hydrochloride | 1885-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dichlorobenzyloxyamine hydrochloride
• 英文别名: O-(2,6-Dichlorobenzyl)hydroxylamine hydrochloride；O-[(2,6-dichlorophenyl)methyl]hydroxylamine;hydrochloride
• CAS: 1885-52-5
• 化学式: C₇H₇Cl₂NO*ClH
• 分子量: 228.506
• InChiKey: ZZAXSKXALNKDRJ-UHFFFAOYSA-N

物化性质

• 熔点：
  206 °C (decomp)(Solv: methanol (67-56-1); ethyl acetate (141-78-6))

计算性质

• 辛醇/水分配系数(LogP)：
  2.81
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 包装等级：
  II
• 危险类别：
  4.1
• 危险性防范说明：
  P240,P210,P241,P264,P280,P302+P352,P370+P378,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险品运输编号：
  1325
• 危险性描述：
  H315,H319,H228

反应信息

• 作为反应物：
  描述：

  2,6-dichlorobenzyloxyamine hydrochloride 、 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 生成 (2S,3R)-N-[(2,6-dichlorophenyl)methoxy]-3-imidazol-1-yl-2-methyl-chroman-4-imine
  参考文献：
  名称：

  Stereoselective synthesis and antifungal activity of (Z)-trans-3-azolyl-2-methylchromanone oxime ethers

  摘要：

  A series of (Z)-trans-3-azolyl-2-methylchromanone oxime ethers were stereoselectively synthesized and tested for in vitro antifungal activity. Many of these derivatives exhibit high activity against Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.08.030

文献信息

• Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof
  申请人：Fensholdt Jef

  公开号：US20070244117A1

  公开（公告）日：2007-10-18

  The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R 1 , A, R 9 , X, B, R 8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer.

  本发明涉及一般式I的化合物，其中D、E、F、G、W、Y、R1、A、R9、X、B、R8如本文所定义，并且其药学上可接受的盐、水合物或溶剂化物，用于治疗与异常血管生成相关的疾病，如癌症，可单独使用或与一个或多个其他药理活性化合物联合使用。
• AZOXY COMPOUND
  申请人：KOWA CO. LTD.

  公开号：EP0396769A1

  公开（公告）日：1990-11-14

  A novel 2-imino derivative of an antifungal substance KA-7367A represented by formula (I) is disclosed. This derivative has a strong antifungal activity and an excellent stability, and is useful, for example, as an antifungal agent for warm-blooded animals including human beings and for use in agricultural and horticultural fields.

  本发明公开了一种由式（I）表示的抗真菌物质 KA-7367A 的新型 2-亚氨基衍生物。这种衍生物具有很强的抗真菌活性和出色的稳定性，可用作温血动物（包括人类）的抗真菌剂，也可用于农业和园艺领域。
• Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0570245A2

  公开（公告）日：1993-11-18

  Compounds of formula (I) : (in which: R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or a heterocyclic group; A is a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y is hydrogen, aryl, cycloalkyl or a heterocyclic group) have the ability to inhibit the biosynthesis of cholesterol, and can thus be used for the treatment and prophylaxis of diseases relating to high blood cholesterol levels.

  式(I)化合物： 其中R为氢、甲基或羟基；X为烷基、烯基、环烷基、芳基、芳烷基或杂环基；A为单键或亚烷基、亚烯基、亚炔基或烷二烯基；Y为氢、芳基、环烷基或杂环基）具有抑制胆固醇生物合成的能力，因此可用于治疗和预防与高血胆固醇水平有关的疾病。
• A new strategy for the synthesis of dioxime ether derivatives with nitromethylene imidazolidine
  作者：Hui Zeng、Zhengjie Dong、Xinfei Chen、Xusheng Shao、Xiaoyong Xu、Zhong Li

  DOI：10.1016/j.tetlet.2015.02.041

  日期：2015.3

  In the studies on oxime ether derivative synthesis, a serendipitous reactivity of dihydropyrroloimidazol-6-ones has been observed. Instead of expected oxime ethers, a new class of 1,2-dioxime ether derivatives with nitromethylene imidazolidine subunit were prepared in moderate to good yields. In this reaction, the adjacent carbon of carbonyl, but not the carbonyl, was preferentially attacked by oxyamine. The methodology has been applied on a wide range of oxyamine hydrochlorides, such as alkoxyamine hydrochlorides and benzyloxyamine hydrochlorides. (C) 2015 Published by Elsevier Ltd.
• Hydroxylamine Chemistry. V. Aralkoxyguanidines¹
  作者：D. G. Martin、E. L. Schumann、W. Veldkamp、H. Keasling

  DOI：10.1021/jm00328a009

  日期：1965.7