1-(4-chloro-2H-benzotriazol-5-yl)-2-methylprop-2-en-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 1-(4-chloro-2H-benzotriazol-5-yl)-2-methylprop-2-en-1-one
• 化学式: C₁₀H₈ClN₃O
• 分子量: 221.64
• InChiKey: FTBJHOZLZRUSFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Shape memory polymer intraocular lenses
  申请人：The Regents of the University of Colorado

  公开号：US10272176B2

  公开（公告）日：2019-04-30

  A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45

  形状记忆聚合物（SMP）眼内透镜的折射率可高于 1.45，Tg 介于 10 摄氏度和 60 摄氏度之间（包括 60 摄氏度），极少或没有闪烁，对可见光谱的透光率基本上为 100%。然后在高于 SMP 材料 Tg 的温度下轧制眼内透镜。眼内装置在模具内径向压缩至直径小于或等于 1.8 毫米，同时保持温度高于 Tg。压缩后的眼内透镜装置可通过角膜或巩膜或其他解剖结构上小于 2 毫米宽的切口插入。晶状体可通过切口插入囊袋、睫状沟或其他空腔。SMP 的折射率可达到大于或等于 1.45
• Intraocular lenses
  申请人：The Regents of the University of Colorado

  公开号：US10286106B2

  公开（公告）日：2019-05-14

  A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

  形状记忆聚合物（SMP）眼内透镜的折射率可高于 1.45，Tg 介于 10 摄氏度和 60 摄氏度之间（包括 60 摄氏度），极少或没有闪烁，对可见光谱的透光率基本上为 100%。然后在高于 SMP 材料 Tg 的温度下轧制眼内透镜。眼内装置在模具内径向压缩至直径小于或等于 1.8 毫米，同时保持温度高于 Tg。压缩后的眼内透镜装置可通过角膜或巩膜或其他解剖结构上小于 2 毫米宽的切口插入。晶状体可通过切口插入囊袋、睫状沟或其他空腔。SMP 的折射率可达到大于或等于 1.45。
• SHAPE MEMORY POLYMER INTRAOCULAR LENSES
  申请人：Abbott Medical Optics Inc.

  公开号：EP3044241A1

  公开（公告）日：2016-07-20
• COMPOSITIONS AND METHODS RELATED TO TAUOPATHY
  申请人：Regents of the University of Minnesota

  公开号：US20140171373A1

  公开（公告）日：2014-06-19

  Disclosed herein are isolated polypeptides, antibody preparations, treatment methods, diagnostic methods, and screening methods related to tauopathy. Generally, the isolated polypeptide includes a core pentapeptide, with the proviso that the isolated polypeptide is not a native full-length tau protein. Generally, the antibody preparations include antibody that specifically binds to SEQ ID NO:12. Generally, the treatment methods include administering to a subject a composition that includes the isolated polypeptide. Generally, the diagnostic methods includes contacting a sample from a subject with an antibody preparation that includes antibody that specifically binds to SEQ ID NO:12, and then detecting a ligand in the sample that specifically binds the antibody preparation. Generally, the screening method includes incubating a mixture of caspase-2, a labeled caspase-2 cleavage substrate, and a test compound under conditions effective to permit the caspase-2 to cleave the caspase-2 cleavage substrate, then determining whether the test compound inhibits cleavage of the substrate by caspase-2.
• INTRAOCULAR LENSES
  申请人：The Regents of the University of Colorado

  公开号：US20160256600A1

  公开（公告）日：2016-09-08

  A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45