N-dimethylaminopropyl-4-dimethylaminopropylamino-1,8-naphthalimide | 1072879-02-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-dimethylaminopropyl-4-dimethylaminopropylamino-1,8-naphthalimide
• 英文别名: 2-[3-(dimethylamino)propyl]-6-{[3-(dimethylamino)propyl]-amino}-1H-benzo[de]isoquinoline-1,3(2H)-dione；2-[3-(Dimethylamino)propyl]-6-[3-(dimethylamino)propylamino]benzo[de]isoquinoline-1,3-dione
• CAS: 1072879-02-7
• 化学式: C₂₂H₃₀N₄O₂
• 分子量: 382.506
• InChiKey: BCNHQJNBOJKOMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  55.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-dimethylaminopropyl-4-dimethylaminopropylamino-1,8-naphthalimide 生成 2-[3-(dimethylamino)propyl]-6-{[3-(dimethylamino)propyl]-amino}-1H-benzo[de]isoquinoline-1,3(2H)-dione hydrochloride
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs

  摘要：

  A series of potential DNA-binding antitumor agents, 2-[omega-(alkylamino) alkyl]-6-{[omega-(alkylamino) alkyl] amino}-1H-benzo[de] isoquinolin-1,3(2H)-diones and 1,7-bis{6-[(omega-(dimethylamino) alkyl) amino]-1,3dioxo-1H-benzo[de] isoquinolin-2(3H)-yl}-4-methyl-4-azaheptanes, have been prepared as mitonafide derivatives. Their DNA-binding ability and cytotoxic activity have been evaluated. Some of the target compounds have shown high DNA affinity as well as relevant cytotoxic properties. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.08.027
• 作为产物：
  描述：

  N,N-二甲基-1,3-二氨基丙烷 以 乙醇 、 二甲基亚砜 为溶剂， 反应 16.5h， 生成 N-dimethylaminopropyl-4-dimethylaminopropylamino-1,8-naphthalimide
  参考文献：
  名称：

  用于铸态有机太阳能电池的氨基萘二甲酰亚胺基分子阴极中间层

  摘要：

  改变所有这些链：从酰亚胺单元和不同的胺侧链分两步合成三个基于酰亚胺的分子（NA、NAA 和 NEA）。带有乙二胺侧链的 NEA 被证明是最有效的。以 NEA 作为阴极夹层的有机太阳能电池的二元和三元混合物的功率转换效率分别为 15.04% 和 15.80%。

  DOI：

  10.1002/cssc.202101383

文献信息

• Aminonaphthalimide‐Based Molecular Cathode Interlayers for As‐Cast Organic Solar Cells
  作者：Yong Zhao、Yang Liu、Xiaojie Liu、Xiao Kang、Liangmin Yu、Shuixing Dai、Mingliang Sun

  DOI：10.1002/cssc.202101383

  日期：2021.11.4

  imide-based molecules (NA, NAA, and NEA) are synthesized in two steps from imide units and different amine side-chains. NEA, with ethylenediamine side-chains, proves most effective. Organic solar cells with NEA as cathode interlayer afforded power conversion efficiencies of 15.04 % and 15.80 % for binary and ternary blends, respectively.

  改变所有这些链：从酰亚胺单元和不同的胺侧链分两步合成三个基于酰亚胺的分子（NA、NAA 和 NEA）。带有乙二胺侧链的 NEA 被证明是最有效的。以 NEA 作为阴极夹层的有机太阳能电池的二元和三元混合物的功率转换效率分别为 15.04% 和 15.80%。
• Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs
  作者：Ippolito Antonini、Rosaria Volpini、Diego Dal Ben、Catia Lambertucci、Gloria Cristalli

  DOI：10.1016/j.bmc.2008.08.027

  日期：2008.9

  A series of potential DNA-binding antitumor agents, 2-[omega-(alkylamino) alkyl]-6-[omega-(alkylamino) alkyl] amino}-1H-benzo[de] isoquinolin-1,3(2H)-diones and 1,7-bis6-[(omega-(dimethylamino) alkyl) amino]-1,3dioxo-1H-benzo[de] isoquinolin-2(3H)-yl}-4-methyl-4-azaheptanes, have been prepared as mitonafide derivatives. Their DNA-binding ability and cytotoxic activity have been evaluated. Some of the target compounds have shown high DNA affinity as well as relevant cytotoxic properties. (C) 2008 Elsevier Ltd. All rights reserved.