8-Ethynylcyclotetradecane-1-carbonyl chloride

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 8-Ethynylcyclotetradecane-1-carbonyl chloride
• 英文别名: 8-ethynylcyclotetradecane-1-carbonyl chloride
• 化学式: C₁₇H₂₇ClO
• 分子量: 282.8
• InChiKey: MJPIQKKJYZTZEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PROTEIN KINASE INHIBITORS (VARIANTS), USE THEREOF IN TREATING ONCOLOGICAL DISEASES AND A PHARMACEUTICAL COMPOSITION BASED THEREON
  申请人：Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma"

  公开号：EP2743266A2

  公开（公告）日：2014-06-18

  The present invention relates to the treatment of oncological, chronic inflammatory and similar diseases with the aid of new families of chemical compounds having improved efficiency with regard to the inhibition of Abl kinase and mutant forms thereof, as well as other therapeutically significant kinases. It describes protein kinase inhibitors in the form of compounds of general formula (I) and compounds of general formula (II), or a tautomer, an individual isomer, a mixture of isomers, a pharmaceutically acceptable salt, a solvate or a hydrate thereof.

  本发明涉及借助新系列化合物治疗肿瘤、慢性炎症和类似疾病，这些化合物在抑制 Abl 激酶及其突变形式以及其他具有治疗意义的激酶方面具有更高的效率。它描述了通式（I）化合物和通式（II）化合物或其同分异构体、单个异构体、异构体混合物、药学上可接受的盐、溶液或水合物形式的蛋白激酶抑制剂。