(2R,4S)-5-biphenyl-4-yl-4-[(5-hydroxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carbonyl)-amino]-2-methyl-pentanoic acid | 1257266-03-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,4S)-5-biphenyl-4-yl-4-[(5-hydroxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carbonyl)-amino]-2-methyl-pentanoic acid
• 英文别名: (2R,4S)-4-[(5-hydroxy-1-methyl-4-oxopyridine-2-carbonyl)amino]-2-methyl-5-(4-phenylphenyl)pentanoic acid
• CAS: 1257266-03-7
• 化学式: C₂₅H₂₆N₂O₅
• 分子量: 434.492
• InChiKey: PIZBYISTTUILQH-UZLBHIALSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2R,4S)-5-biphenyl-4-yl-4-[(5-hydroxy-4-oxo-4H-pyran-2-carbonyl)-amino]-2-methyl-pentanoic acid ethylester 、 甲胺 以 水 为溶剂， 反应 6.0h， 生成 (2R,4S)-5-biphenyl-4-yl-4-[(5-hydroxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carbonyl)-amino]-2-methyl-pentanoic acid
  参考文献：
  名称：

  [EN] SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS
  [FR] DÉRIVÉS AMINOBUTYRIQUES SUBSTITUÉS EN TANT QU'INHIBITEURS DE NÉPRILYSINE

  摘要：

  公开号：

  WO2010136474A3

文献信息

• [EN] METHOD FOR OBTAINING AN OPTICALLY PURE 1,2,3,4 TETRAHYDRO-ISOQUINOLINE DERIVATIVE<br/>[FR] PROCÉDÉ D'OBTENTION D'UN DÉRIVÉ DE 1,2,3,4-TÉTRAHYDRO-ISOQUINOLÉINE OPTIQUEMENT PUR
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2010064212A1

  公开（公告）日：2010-06-10

  The invention relates to a method for obtaining enantiomerically enriched 6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline from a mixture of (R)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline and (S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline.

  该发明涉及一种从(R)-6,7-二甲氧基-1-[2-(4-三氟甲基苯基)-乙基]-1,2,3,4-四氢异喹啉和(S)-6,7-二甲氧基-1-[2-(4-三氟甲基苯基)-乙基]-1,2,3,4-四氢异喹啉混合物中获取对映体富集的6,7-二甲氧基-1-[2-(4-三氟甲基苯基)-乙基]-1,2,3,4-四氢异喹啉的方法。
• Substituted aminobutyric derivatives as neprilysin inhibitors
  申请人：Novartis AG

  公开号：US08263629B2

  公开（公告）日：2012-09-11

  The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供公式I′的化合物；或其药学上可接受的盐，其中R1、R2、R3、X和n在此定义。本发明还涉及一种制造本发明化合物的方法及其治疗用途。本发明还提供了一种药理活性剂的组合物和制药组合物。
• Substituted Aminobutyric Derivatives as Neprilysin Inhibitors
  申请人：Coppola Gary Mark

  公开号：US20120252830A1

  公开（公告）日：2012-10-04

  The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了公式I'的化合物；或其药学上可接受的盐，其中R1、R2、R3、X和n在此定义。本发明还涉及制造本发明化合物的方法及其治疗用途。本发明还提供了一种药理活性剂的组合和制药组合物。
• SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS
  申请人：COPPOLA Gary Mark

  公开号：US20150174089A1

  公开（公告）日：2015-06-25

  The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了式I'的化合物；或其药学上可接受的盐，其中R1、R2、R3、X和n在此定义。本发明还涉及制造本发明中化合物的方法及其治疗用途。本发明还提供了一种药理活性剂的组合和一种制药组合物。
• US8263629B2
  申请人：——

  公开号：US8263629B2

  公开（公告）日：2012-09-11