[(3S,4R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,4R,5R)-6-[(1R,2S)-1,2-dihydroxy-3-[2-(2-methoxyethoxy)ethylsulfanyl]propyl]-2-formyl-4-hydroxy-5-methyloxan-2-yl] hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: [(3S,4R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,4R,5R)-6-[(1R,2S)-1,2-dihydroxy-3-[2-(2-methoxyethoxy)ethylsulfanyl]propyl]-2-formyl-4-hydroxy-5-methyloxan-2-yl] hydrogen phosphate
• 化学式: C₂₄H₄₀N₃O₁₅PS
• 分子量: 673.6
• InChiKey: IRJJRBQNRGERQM-HUTSINHASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  44
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  295
• 氢给体数：
  7
• 氢受体数：
  16

文献信息

• Factor IX: Remodeling and Glycoconjugation of Factor IX
  申请人：Novo Nordisk A/S

  公开号：US20140170728A1

  公开（公告）日：2014-06-19

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• GLYCOPEGYLATION METHODS AND PROTEINS/PEPTIDES PRODUCED BY THE METHODS
  申请人：Novo Nordisk A/S

  公开号：US20140294762A1

  公开（公告）日：2014-10-02

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII
  申请人：Novo Nordisk A/S

  公开号：US20160193353A1

  公开（公告）日：2016-07-07

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.