[1-[(1R)-3-(2,4-dioxopyrimidin-1-yl)cyclopentyl]-2-methylbutan-2-yl]oxy-pentan-3-ylphosphinic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [1-[(1R)-3-(2,4-dioxopyrimidin-1-yl)cyclopentyl]-2-methylbutan-2-yl]oxy-pentan-3-ylphosphinic acid
• 化学式: C₁₉H₃₃N₂O₅P
• 分子量: 400.4
• InChiKey: UPPUTRFQDJFUPD-TZGCNFNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] MODIFIED POLYNUCLEOTIDES FOR ALTERING CELL PHENOTYPE<br/>[FR] POLYNUCLÉOTIDES MODIFIÉS POUR MODIFIER LE PHÉNOTYPE CELLULAIRE
  申请人：MODERNA THERAPEUTICS INC

  公开号：WO2014093574A1

  公开（公告）日：2014-06-19

  The present invention relates to compositions, methods and kits using cell phenotype altering polynucleotides, cell phenotype altering primary transcripts and cell phenotype altering mmRNA molecules.The invention relates to compositions, methods and kits using modified RNA to alter the phenotype of cells. The modified RNA of the invention may encode peptides, polypeptides or multiple proteins. The modified RNA of the invention may also be used to alter the phenotype of cells to produce cell phenotype altering polypeptides of interest.