1-O-[(1S,18E,20S)-19-methoxy-5,7-dioxa-13-azatetracyclo[11.7.1.02,10.04,8]henicosa-2,4(8),9,18-tetraen-20-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 1-O-[(1S,18E,20S)-19-methoxy-5,7-dioxa-13-azatetracyclo[11.7.1.02,10.04,8]henicosa-2,4(8),9,18-tetraen-20-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• 化学式: C₃₀H₄₃NO₉
• 分子量: 561.7
• InChiKey: LRVLHTXMYKRIJX-UTWGRPFSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• ACYLATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
  申请人：Xu Rongzhen

  公开号：US20140303147A1

  公开（公告）日：2014-10-09

  The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel homoharringtonine acylated derivatives of formula (I) and formula (II) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

  本发明属于天然药物和制药化学领域，涉及公式（I）和公式（II）的新型羟基哈林汀酰化衍生物及其药学上可接受的盐，以及制备这些化合物的方法，含有这些化合物的组合物以及它们在制备抗肿瘤药物中的应用。
• AMINATED DERIVATIVE OF HOMOHARRINGTONINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
  申请人：Rong Frank

  公开号：US20140206669A1

  公开（公告）日：2014-07-24

  The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel aminated homoharringtonine derivatives of formula (I) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

  本发明属于天然药物和药学化学领域，具体涉及公式（I）的新型氨基化的同蒿芦丁衍生物及其药学上可接受的盐，制备这些化合物的方法，含有这些化合物的组合物以及它们在制备抗肿瘤药物方面的用途。
• Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof
  申请人：ALBANY MOLECULAR RESEARCH, INC.

  公开号：US10597401B2

  公开（公告）日：2020-03-24

  The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.

  本发明涉及奥美他辛及其头孢他辛衍生物的制备方法和中间体。所得产品可用于增殖性疾病和传染性疾病的治疗。
• Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
  申请人：Race Oncology Ltd.

  公开号：US11135201B2

  公开（公告）日：2021-10-05

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof. Such methods and compositions are particularly useful for treatment of malignancies.

  本发明描述了通过提高单一疗法的疗效或减少副作用来改善以前因治疗效果不理想而受到限制的治疗剂的疗效的方法和组合物。这种方法和组合物特别适用于双蒽或其衍生物、类似物或原药。此类方法和组合物尤其适用于恶性肿瘤的治疗。
• METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF
  申请人：ALBANY MOLECULAR RESEARCH, INC.

  公开号：US20180134724A1

  公开（公告）日：2018-05-17

  The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.