2-α-hydroxyethyl-thiamine pyrophosphate | 20319-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-α-hydroxyethyl-thiamine pyrophosphate
• 英文别名: 2-(α-hydroxyethyl) thiamine diphosphate；2-(alpha-Hydroxyethyl) thiamine diphosphate；2-(a-hydroxyethyl) thiamine pyrophosphate；2-(1-hydroxyethyl)thiamine diphosphate；3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-5-(2-((hydroxy(phosphonooxy)phosphoryl)oxy)ethyl)-2-(1-hydroxyethyl)-4-methylthiazol-3-ium Chloride；2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate;chloride
• CAS: 20319-27-1
• 化学式: C₁₄H₂₃N₄O₈P₂S*Cl
• 分子量: 504.825
• InChiKey: NOXQCKAOUMGQCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  217
• 氢给体数：
  5
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  3-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(1-(tert-butoxy)-2-hydroxy-1-oxopropan-2-yl)-5-(2-((hydroxy(phosphonooxy)phosphoryl)oxy)ethyl)-4-methylthiazol-3-ium chloride 在 三氟乙酸 作用下， 反应 0.25h， 生成 2-α-hydroxyethyl-thiamine pyrophosphate
  参考文献：
  名称：

  Interaction of pyruvate-thiamin diphosphate adducts with pyruvate decarboxylase. Catalysis through "closed" transition states

  摘要：

  DOI：

  10.1021/ja00395a038

文献信息

• Methods and microorganisms for the production of 1,3-butanediol
  申请人：THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

  公开号：US10626423B2

  公开（公告）日：2020-04-21

  A non-naturally occurring microorganism having a 1,3-BDO pathway is provided. The microorganism expresses at least one of the following 1,3-BDO pathway enzymes: an aldolase that catalyzes condensation of two acetaldehydes to produce 3-hydroxybutanal; and an aldo-ketoreductase, oxidoreductase, aldehyde reductase or alcohol dehydrogenase that reduces 3-hydroxybutanal to 1,3-BDO. The organism may further express one or more enzymes for producing acetaldehyde. A biosynthetic process involves condensing two acetaldehyde molecules to 3-hydroxybutanal using an enzyme from class aldolases; and selectively reducing 3-hydroxybutanal to 1,3-BDO using an enzyme belonging to the class aldo-ketoreductase, oxidoreductase, aldehyde reductase or alcohol dehydrogenase. The process can further include producing acetaldehyde by a biosynthetic method.

  提供了一种具有 1,3-BDO 途径的非天然微生物。该微生物表达至少一种以下 1,3-BDO 途径酶：催化两种乙醛缩合生成 3-hydroxybutanal 的醛醇酶；以及将 3-hydroxybutanal 还原成 1,3-BDO 的醛酮还原酶、氧化还原酶、醛还原酶或醇脱氢酶。生物体可进一步表达一种或多种产生乙醛的酶。生物合成过程包括使用醛缩酶类的酶将两个乙醛分子缩合为 3-羟基丁醛；使用属于醛酮还原酶、氧化还原酶、醛还原酶或醇脱氢酶类的酶选择性地将 3-羟基丁醛还原为 1,3-BDO。该工艺还可包括通过生物合成法生产乙醛。
• BEARNE, STEPHEN L.;GISH, GERALD;KARIMIAN, KHASHAYAR;KLUGER, RONALD, BIOORG. CHEM., 17,(1989) N, C. 224-230
  作者：BEARNE, STEPHEN L.、GISH, GERALD、KARIMIAN, KHASHAYAR、KLUGER, RONALD

  DOI：——

  日期：——
• AUTO-INDUCIBLE EXPRESSION SYSTEM, AND THE USE THEREOF FOR PRODUCING USEFUL METABOLITES USING A BACTERIUM OF THE FAMILY ENTEROBACTERIACEAE
  申请人：Ajinomoto Co., Inc.

  公开号：EP2834360B1

  公开（公告）日：2018-05-23
• METHODS AND MICROORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
  申请人：The Governing Council of the University of Toronto

  公开号：EP3325608B1

  公开（公告）日：2021-11-24
• Method and Device for Thermal Conditioning of a Cell
  申请人：Dauner Michael

  公开号：US20070298484A1

  公开（公告）日：2007-12-27

  The invention relates to methods and agents for thermal conditioning of a biological cell, methods and uses of said agents for releasing and insulating ingredients outside the biological cell, and for quantitatively and qualitatively detecting the released ingredient and to a method for sampling biological cells which consists in carrying out in one step the sampling said biological cells in a culture medium and in releasing cellular ingredients during said sampling. Sampling devices are also disclosed.