申请人:Purdue Pharma L.P.
公开号:US20140179724A1
公开(公告)日:2014-06-26
The application is directed to compounds of Formula I′-A
especially to compounds of Formula I-A
and pharmaceutically acceptable salts and solvates thereof, wherein R
1a
-R
5a
, Y, Z are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I′-A, and especially compounds of Formula I-A, to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.