ethyl 1-diethoxyphosphinyl-1-cyclobutanecarboxylate | 15916-49-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: ethyl 1-diethoxyphosphinyl-1-cyclobutanecarboxylate
• 英文别名: 1-Carboethoxy-cyclobutanphosphonsaeure-diethylester；Ethyl 1-(diethoxyphosphoryl)cyclobutanecarboxylate；ethyl 1-diethoxyphosphorylcyclobutane-1-carboxylate
• CAS: 15916-49-1
• 化学式: C₁₁H₂₁O₅P
• 分子量: 264.259
• InChiKey: WLRCHDGVAFFHSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 1-diethoxyphosphinyl-1-cyclobutanecarboxylate 在 劳森试剂 、 sodium hydroxide 作用下， 以 乙醇 、 邻二甲苯 、 水 为溶剂， 反应 29.0h， 生成 1-diethoxythiophosphinyl-1-cyclobutanecarboxylic acid
  参考文献：
  名称：

  Synthesis of thiophosphoryl-substituted derivatives of cycloalkanecarboxylic acids

  摘要：

  The 1-thiophosphorylated esters and nitriles of cycloalkanecarboxylic acids were obtained both by the direct reaction of derivatives of thiophosphorylacetic acids with alpha,omega-dihalogenoalkanes in the K2CO3/DMSO heterophasic system, and as a result of the reaction of the corresponding oxygen compounds with the Louson reagent.

  DOI：

  10.1007/bf00869520
• 作为产物：
  描述：

  磷酰基乙酸三乙酯 、 1,3-二溴丙烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以60%的产率得到ethyl 1-diethoxyphosphinyl-1-cyclobutanecarboxylate
  参考文献：
  名称：

  Nasser, Jamal; About-Jaudet, Elie; Collignon, Noel, Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 54, # 1/4, p. 171 - 179

  摘要：

  DOI：

文献信息

• Cycloalkylation of compounds in the series of phosphorus-substituted derivatives of acetic acid
  作者：P. V. Kazakov、I. L. Odinets、A. P. Laretina、T. M. Shcherbina、P. V. Petrovskii、L. V. Kovalenko、T. A. Mastryukova

  DOI：10.1007/bf00961505

  日期：1990.8

  1-Phosphoryl-substituted cyclopropanes, cyclobutanes, and cyclopentanes were obtained by the reaction of phosphoryl-substituted esters and nitriles of acetic acid with alpha,omega-dihaloalkanes. The influence of the CH-acidity of the starting compounds and electrophilicity of the alkylating agent on the reaction rate was examined.
• KAZAKOV, P. V.;ODINETS, I. L.;LARETINA, A. P.;SHCHERBINA, T. M.;PETROVSKI+, IZV. AN CCCP. CEP. XIM.,(1990) N, S. 1873-1880
  作者：KAZAKOV, P. V.、ODINETS, I. L.、LARETINA, A. P.、SHCHERBINA, T. M.、PETROVSKI+

  DOI：——

  日期：——
• NASSER, JAMAL;ABOUT-JAUDET, ELIE;COLLIGNON, NOEL, PHOSPH., SULFUR AND SILICON AND RELAT. ELEM., 54,(1990) N-4, C. 171-179
  作者：NASSER, JAMAL、ABOUT-JAUDET, ELIE、COLLIGNON, NOEL

  DOI：——

  日期：——
• Some properties of 1-phosphorus(IV)-substituted cycloalkanecarboxylic acids and their derivatives
  作者：I. L. Odinets、P. V. Kazakov、R. U. Amanov、M. Yu. Antipin、L. V. Kovalenko、Yu. T. Struchkov、T. A. Mastryukova

  DOI：10.1007/bf00864348

  日期：1992.8

  An x-ray structural study of single crystals of 1-diphenylphosphinyl-cyclo-propane- and 1-diphenylphosphinylcyclobutanecarboxylic acids was conducted. 1-Phosphorylated cycloalkanecarboxylic acid amides were obtained from the corresponding acids by the reaction with thionyl chloride with subsequent treatment with primary and secondary amines. It was shown that the reaction of 1-phosphorylated 1-functional substituted cycloalkanes with trimethylbromosilane takes place with preservation of the cyclic structure and yields phosphoric acid silyl esters, and the corresponding cycloalkylphosphonic and cycloalkylphosphinic acids were synthesized by their hydrolysis in soft conditions.
• Nasser, Jamal; About-Jaudet, Elie; Collignon, Noel, Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 54, # 1/4, p. 171 - 179
  作者：Nasser, Jamal、About-Jaudet, Elie、Collignon, Noel

  DOI：——

  日期：——