(4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;nitric acid

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;nitric acid
• 化学式: C18H22N2O6
• 分子量: 362.4
• InChiKey: QSJJECHFXIMPRT-RNWHKREASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.59
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• OPIOID DOSAGE FORMS HAVING DOSE PROPORTIONAL STEADY STATE CAVE AND AUC AND LESS THAN DOSE PROPORTIONAL SINGLE DOSE CMAX
  申请人：Purdue Pharma L.P.

  公开号：US20140187572A1

  公开（公告）日：2014-07-03

  The present invention relates to a plurality of dosage forms comprising a first dosage form and second dosage form each comprising a therapeutic agent, such as an opioid; wherein the dosage strength of the second dosage form is greater than that of the first dosage form; and wherein the steady state C ave and the steady state AUC of the first and second dosage forms are dose proportional and the single dose C max of the second dosage form is less than the minimum level for dose proportionality with respect to the first dosage form. The present invention also relates to methods of administering such dosage forms to a patient, as well as to kits comprising such dosage forms and instructions for administration of the dosage forms to a patient. The inventors believe that the dosage forms and methods of the present invention will lead to improved safety and patient acceptance.
• US9034377B2
  申请人：——

  公开号：US9034377B2

  公开（公告）日：2015-05-19