[6-methyl-4-(trifluoromethyl)-1H-benzimidazol-2-yl]methanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: [6-methyl-4-(trifluoromethyl)-1H-benzimidazol-2-yl]methanamine
• 化学式: C₁₀H₁₀F₃N₃
• 分子量: 229.2
• InChiKey: LXFFOTXWUJQEFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• BENZIMIDAZOLE INHIBITORS OF THE SODIUM CHANNEL
  申请人：Pajouhesh Hassan

  公开号：US20140187533A1

  公开（公告）日：2014-07-03

  The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions. Formula (I)

  本发明涉及用于治疗与电压门控离子通道功能相关的疾病的化合物，特别是与钠通道活性相关的疾病。更具体地说，本发明涉及化合物（例如，按照任何公式（I）-（XIII）或表1的化合物（1）-（236）的化合物），这些化合物对于治疗各种疾病和病况是有用的。公式（I）
• Benzimidazole Inhibitors of the Sodium Channel
  申请人：DeGiacomo Mark G.

  公开号：US20170260130A1

  公开（公告）日：2017-09-14

  The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.
• US9688615B2
  申请人：——

  公开号：US9688615B2

  公开（公告）日：2017-06-27