1-[(1S,5R)-9-[(1R,6S)-8-bicyclo[4.3.1]decanyl]-9-azabicyclo[3.3.1]nonan-3-yl]-2-(1H-1,2,4-triazol-5-yl)benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-[(1S,5R)-9-[(1R,6S)-8-bicyclo[4.3.1]decanyl]-9-azabicyclo[3.3.1]nonan-3-yl]-2-(1H-1,2,4-triazol-5-yl)benzimidazole
• 化学式: C₂₇H₃₆N₆
• 分子量: 444.6
• InChiKey: XJJHZDGRNATWSX-HPSKKDDCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SUBSTITUTED BENZIMIDAZOLE-TYPE PIPERIDINE COMPOUNDS AND USES THEREOF
  申请人：Purdue Pharma L.P.

  公开号：US20150322066A1

  公开（公告）日：2015-11-12

  The disclosure relates to Substituted Benzimidazole-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable salts or solvates thereof, e.g., a pharmaceutically acceptable salt or solvate, wherein R 1 , R 2 , R 3 , Q a , W, U, A, B, Z, a, and the dashed lines are as defined herein, compositions comprising an effective amount of a Substituted Benzimidazole-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Benzimidazole-Type Piperidine Compound.
• US9598411B2
  申请人：——

  公开号：US9598411B2

  公开（公告）日：2017-03-21