3-(4-Methyl-2,3-dihydro-1,3-thiazol-2-yl)-7-nitroso-8-(pyrrolidin-1-ylmethyl)chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(4-Methyl-2,3-dihydro-1,3-thiazol-2-yl)-7-nitroso-8-(pyrrolidin-1-ylmethyl)chromen-2-one
• 英文别名: 3-(4-methyl-2,3-dihydro-1,3-thiazol-2-yl)-7-nitroso-8-(pyrrolidin-1-ylmethyl)chromen-2-one
• 化学式: C₁₈H₁₉N₃O₃S
• 分子量: 357.4
• InChiKey: PROWCZDSLOANMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  96.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION
  申请人：President and Fellows of Harvard College

  公开号：US20140187444A1

  公开（公告）日：2014-07-03

  The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention is also useful for identifying therapeutic compounds to treat de-glycosylation-associated disorders such as ischemic damage and traumatic injury. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins and also relates in part to compounds to treat glycosylation-associated diseases and disorders.
• US8993718B2
  申请人：——

  公开号：US8993718B2

  公开（公告）日：2015-03-31