1-(2-Sulfanylphenyl)ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 1-(2-Sulfanylphenyl)ethanol
• 英文别名: 1-(2-sulfanylphenyl)ethanol
• 化学式: C₈H₁₀OS
• 分子量: 154.23
• InChiKey: ZUZHKVHXRSAORH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] INHIBITORS OF THE USP1/UAF1 DEUBIQUITINASE COMPLEX AND USES THEREOF<br/>[FR] INHIBITEURS DU COMPLEXE USP1/UAF1 DÉSUBIQUITINASE ET LEURS UTILISATIONS
  申请人：US HEALTH

  公开号：WO2014105952A2

  公开（公告）日：2014-07-03

  Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R1, R2, and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damaging agents in cancer treatment. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a heterodimeric deubiquitinase complex in a cell, and a method of enhancing the chemotherapeutic treatment of cancer in a mammal undergoing treatment with an anti cancer agent. Further disclosed is a method of preparing compounds of the invention.