5-{5-chloro-2-[2-(3-methylphenoxy)ethoxy]benzylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-{5-chloro-2-[2-(3-methylphenoxy)ethoxy]benzylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• 英文别名: 5-[[5-chloro-2-[2-(3-methylphenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
• 化学式: C₂₀H₁₇ClN₂O₄S
• mdl: MFCD03145191
• 分子量: 416.9
• InChiKey: RIXWTBUZCUKTHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel molecules for regulating cell death
  申请人：Nunnari Jodi

  公开号：US20050038051A1

  公开（公告）日：2005-02-17

  The present invention provides compounds capable of regulating apoptosis, e.g., via regulating mitochondrial fission or fusion. The present invention also provides methods of screening for compounds capable of regulating apoptosis and methods of treating conditions association with apoptosis.

  本发明提供了能够调节细胞凋亡的化合物，例如通过调节线粒体裂变或融合。本发明还提供了筛选能够调节细胞凋亡的化合物的方法以及治疗与细胞凋亡有关的疾病的方法。
• NOVEL MOLECULES FOR REGULATING CELL DEATH
  申请人：Nunnari Jodi

  公开号：US20080287473A1

  公开（公告）日：2008-11-20

  The present invention provides compounds capable of regulating apoptosis, e.g., via regulating mitochondrial fission or fusion. The present invention also provides methods of screening for compounds capable of regulating apoptosis and methods of treating conditions association with apoptosis.
• US8450333B2
  申请人：——

  公开号：US8450333B2

  公开（公告）日：2013-05-28
• [EN] NOVEL MOLECULES FOR REGULATING CELL DEATH<br/>[FR] NOUVELLES MOLECULES POUR LA REGULATION DE LA MORT CELLULAIRE
  申请人：UNIV CALIFORNIA

  公开号：WO2005051974A2

  公开（公告）日：2005-06-09

  The present invention provides compounds capable of regulating apoptosis, e.g., via regulating mitochondrial fission or fusion. The present invention also provides methods of screening for compounds capable of regulating apoptosis and methods of treating conditions association with apoptosis.