1-(4-Methoxy-benzoyl)-4-(4-methoxy-phenyl)-pyrrolidon-(2) | 24343-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(4-Methoxy-benzoyl)-4-(4-methoxy-phenyl)-pyrrolidon-(2)
• 英文别名: 1-(4-methoxybenzoyl)-4-(4-methoxyphenyl)pyrrolidin-2-one
• CAS: 24343-91-7
• 化学式: C₁₉H₁₉NO₄
• 分子量: 325.364
• InChiKey: GKHWIBWAUVEMJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(2-bromoprop-2-enyl)-N-(4-methoxybenzoyl)-4-methoxybenzamide 、 三正丁基氢锡 在 偶氮二异丁腈 作用下， 以 苯 为溶剂， 反应 4.0h， 生成 1-(4-Methoxy-benzoyl)-4-(4-methoxy-phenyl)-pyrrolidon-(2) 、 N-(4-methoxybenzoyl)-N-(prop-2-enyl)-4-methoxybenzamide 、 、 6-methoxy-2-(4-methoxybenzoyl)-4-methylene-3,4-dihydroisoquinolin-1(2H)-one 、 5-methoxy-2-[2-(4-methoxyphenyl)prop-2-enyl]isoindoline-1,3-dione 、 6-methoxy-2-(4-methoxybenzoyl)-4-[(tributylstannyl)methyl]-3,4-dihydroisoquinolin-1(2H)-one 、 N-(4-methoxybenzoyl)-4-methoxy-2-[3-(tributylstannyl)prop-1-en-2-yl]benzamide
  参考文献：
  名称：

  Radical 1,4-aryl transfer in arylcarboxamides leading to phthalimides, biaryls and enantiomerically enriched β-arylethylamines

  摘要：

  5-exo Cyclisation of vinyl-, aryl- and alkyl-radicals onto the aryl group of arylcarboxamides is followed by beta-scission of the resulting spirocyclohexadienyl radicals with ejection of a carbamoyl radical. The fate of this radical depends on the substrate but, in the cases studied, either 5-endo cyclisation or direct reduction follows to give phthalimides, biaryls or beta-arylethylamines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.118

文献信息

• Radical 1,4-aryl transfer in arylcarboxamides leading to phthalimides, biaryls and enantiomerically enriched β-arylethylamines
  作者：Jeremy Robertson、Matthew J. Palframan、Stephen A. Shea、Kirill Tchabanenko、William P. Unsworth、Chase Winters

  DOI：10.1016/j.tet.2008.07.118

  日期：2008.12

  5-exo Cyclisation of vinyl-, aryl- and alkyl-radicals onto the aryl group of arylcarboxamides is followed by beta-scission of the resulting spirocyclohexadienyl radicals with ejection of a carbamoyl radical. The fate of this radical depends on the substrate but, in the cases studied, either 5-endo cyclisation or direct reduction follows to give phthalimides, biaryls or beta-arylethylamines. (C) 2008 Elsevier Ltd. All rights reserved.