5-(3-aminoprop-1-ynyl)-6-[5-(deuteriomethyl)-4-hydroxyoxolan-2-yl]-1H-pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(3-aminoprop-1-ynyl)-6-[5-(deuteriomethyl)-4-hydroxyoxolan-2-yl]-1H-pyrimidine-2,4-dione
• 化学式: C12H15N3O4
• 分子量: 266.27
• InChiKey: HOVRVTBNTPZDJD-MICDWDOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES
  申请人：Biosearch Technologies, Inc.

  公开号：US20140194611A1

  公开（公告）日：2014-07-10

  The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.