4-methoxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzenesulfonamide | 515859-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-methoxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzenesulfonamide
• CAS: 515859-60-6
• 化学式: C₁₇H₁₉NO₃S
• 分子量: 317.409
• InChiKey: MAXCVQJEIFDLFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,2,3,4-四氢萘 、 对甲氧基苯磺酰胺 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 硝基甲烷 为溶剂， 反应 4.0h， 以64%的产率得到4-methoxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzenesulfonamide
  参考文献：
  名称：

  DDQ-mediated direct oxidative coupling of amides with benzylic and allylic sp3 C–H bonds under metal-free conditions

  摘要：

  A simple and efficient method for the direct oxidative coupling of amides with benzylic and allylic sp(3) C-H bonds using DDQ as an oxidant is described. A range of amides including benzamide, benzyl carbamate, and substituted sulfonamides reacted efficiently with various benzylic and allylic substrates under metal free conditions to afford amidation products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.137

文献信息

• DDQ-mediated direct oxidative coupling of amides with benzylic and allylic sp3 C–H bonds under metal-free conditions
  作者：D. Ramesh、U. Ramulu、K. Mukkanti、Y. Venkateswarlu

  DOI：10.1016/j.tetlet.2012.03.137

  日期：2012.6

  A simple and efficient method for the direct oxidative coupling of amides with benzylic and allylic sp(3) C-H bonds using DDQ as an oxidant is described. A range of amides including benzamide, benzyl carbamate, and substituted sulfonamides reacted efficiently with various benzylic and allylic substrates under metal free conditions to afford amidation products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.