tert-butyl 2-(2-methyl-2-phenylpropyl)-6-oxo-5-phenylmethoxy-1H-pyrimidine-4-carboxylate;2-(2-methyl-2-phenylpropyl)-6-oxo-5-phenylmethoxy-1H-pyrimidine-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: tert-butyl 2-(2-methyl-2-phenylpropyl)-6-oxo-5-phenylmethoxy-1H-pyrimidine-4-carboxylate;2-(2-methyl-2-phenylpropyl)-6-oxo-5-phenylmethoxy-1H-pyrimidine-4-carboxylic acid
• 化学式: C48H52N4O8
• 分子量: 812.9
• InChiKey: AMXURDLQPQVCJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.39
• 重原子数：
  60
• 可旋转键数：
  16
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  165
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE
  申请人：Savira Pharmaceuticals GmbH

  公开号：EP2943495A1

  公开（公告）日：2015-11-18
• [EN] PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE<br/>[FR] DÉRIVÉS PYRIMIDONE ET LEUR UTILISATION DANS LE TRAITEMENT, L'AMÉLIORATION OU LA PRÉVENTION D'UNE MALADIE VIRALE
  申请人：SAVIRA PHARMACEUTICALS GMBH

  公开号：WO2014108406A1

  公开（公告）日：2014-07-17

  The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph,codrug, cocrystal,prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.