(2Z)-2-cyano-N-(3-methoxypropyl)-2-[3-(3-methoxypropylamino)cyclohex-2-en-1-ylidene]acetamide;4-phenyl-1H-benzimidazole-2-sulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (2Z)-2-cyano-N-(3-methoxypropyl)-2-[3-(3-methoxypropylamino)cyclohex-2-en-1-ylidene]acetamide;4-phenyl-1H-benzimidazole-2-sulfonic acid
• 化学式: C43H47N7O9S2
• 分子量: 870.0
• InChiKey: PYQKJTRUBCXIIR-LVEHXPSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.61
• 重原子数：
  61
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  266
• 氢给体数：
  6
• 氢受体数：
  13

文献信息

• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE, AN ORGANIC UVB-SCREENING AGENT AND AN ADDITIONAL ORGANIC UVA-SCREENING AGENT
  申请人：L'OREAL

  公开号：US20150366769A1

  公开（公告）日：2015-12-24

  The present invention relates to a cosmetic or dermatological composition comprising, in a physiologically acceptable support: a) at least one oily phase and b) at least one merocyanine compound of formula (1) defined hereinbelow and c) at least one organic UVB-screening agent chosen from: v) a liquid lipophilic organic UVB-screening agent vi) a hydrophilic organic UVB-screening agent vii) a triazine UVB-screening agent and viii) mixtures thereof; and d) at least one organic UVA-screening agent other than the said merocyanine compound; when the said UVB-screening agent is liquid and lipophilic, the said composition contains less than 2% by weight of cyclohexasiloxane relative to the total weight of the composition. Another subject of the present invention consists of a non-therapeutic cosmetic process for caring for and/or making up a keratin material, comprising the application, to the surface of the said keratin material, of at least one composition according to the invention as defined above. The invention also relates to a non-therapeutic cosmetic process for limiting the darkening of the skin and/or improving the colour and/or uniformity of the complexion, comprising the application, to the surface of the keratin material, of at least one composition as defined previously. The invention also relates to a non-therapeutic cosmetic process for preventing and/or treating the signs of ageing of a keratin material, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.

  本发明涉及一种化妆品或皮肤科学组合物，包括在生理上可接受的载体中：a）至少一种油性相和b）至少一种公式（1）所定义的Merocyanine化合物，c）至少一种有机UVB筛选剂，其中包括：v）一种液态亲脂性有机UVB筛选剂，vi）一种亲水性有机UVB筛选剂，vii）三嗪类UVB筛选剂和viii）它们的混合物；d）除所述Merocyanine化合物之外的至少一种有机UVA筛选剂；当所述UVB筛选剂为液态和亲脂性时，所述组合物相对于组合物的总重量含有不到2％的环己二硅氧烷重量。本发明的另一个主题是非治疗性化妆过程，用于护理和/或化妆角蛋白质材料，包括将至少一种根据上述发明定义的组合物应用于所述角蛋白质材料的表面。本发明还涉及一种非治疗性化妆过程，用于限制皮肤变黑和/或改善肤色和/或均匀性，包括将至少一种如上所述的组合物应用于角蛋白质材料的表面。本发明还涉及一种非治疗性化妆过程，用于预防和/或治疗角蛋白质材料的衰老迹象，包括将至少一种如上所述的组合物应用于角蛋白质材料的表面。
• [EN] COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE, AN ORGANIC UVB-SCREENING AGENT AND AN ADDITIONAL ORGANIC UVA-SCREENING AGENT<br/>[FR] COMPOSITION COSMÉTIQUE OU DERMATOLOGIQUE COMPRENANT UNE MÉROCYANINE, UN AGENT ANTI-UVB ORGANIQUE ET UN AGENT ANTI-UVA ORGANIQUE SUPPLÉMENTAIRE
  申请人：OREAL

  公开号：WO2014111574A1

  公开（公告）日：2014-07-24

  The present invention relates to a cosmetic or dermatological composition comprising, in a physiologically acceptable support: a) at least one oily phase and b) at least one merocyanine compound of formula (1 ) defined hereinbelow and c) at least one organic UVB-screening agent chosen from: v) a liquid lipophilic organic UVB-screening agent vi) a hydrophilic organic UVB-screening agent vii) a triazine UVB-screening agent and viii) mixtures thereof; and d) at least one organic UVA-screening agent other than the said merocyanine compound; when the said UVB-screening agent is liquid and lipophilic, the said composition contains less than 2% by weight of cyclohexasiloxane relative to the total weight of the composition. Another subject of the present invention consists of a non-therapeutic cosmetic process for caring for and/or making up a keratin material, comprising the application, to the surface of the said keratin material, of at least one composition according to the invention as defined above. The invention also relates to a non-therapeutic cosmetic process for limiting the darkening of the skin and/or improving the colour and/or uniformity of the complexion, comprising the application, to the surface of the keratin material, of at least one composition as defined previously. The invention also relates to a non-therapeutic cosmetic process for preventing and/or treating the signs of ageing of a keratin material, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.

  本发明涉及一种化妆品或皮肤科学组合物，其中包括以下生理可接受的支持物：a）至少一种油性相和b）至少一种在下文中定义的公式（1）的美拉氰化合物和c）至少一种有机UVB筛选剂，选择自：v）液态亲脂性有机UVB筛选剂vi）亲水性有机UVB筛选剂vii）三嗪类UVB筛选剂和viii）它们的混合物；以及d）至少一种有机UVA筛选剂，除了所述的美拉氰化合物之外；当所述UVB筛选剂为液态和亲脂性时，所述组合物相对于组合物的总重量含有不到2％的环己硅氧烷。本发明的另一个主题是一种非治疗性化妆过程，用于护理和/或化妆角蛋白材料，包括将至少一种根据上述定义的本发明组合物应用于所述角蛋白材料的表面。本发明还涉及一种非治疗性化妆过程，用于限制皮肤的黑化和/或改善肤色和/或均匀性，包括将至少一种如上所述的组合物应用于角蛋白材料的表面。本发明还涉及一种非治疗性化妆过程，用于预防和/或治疗角蛋白材料的衰老迹象，包括将至少一种如上所述的组合物应用于角蛋白材料的表面。
• Cosmetic or dermatological composition comprising a merocyanine, an organic UVB-screening agent and an additional organic UVA-screening agent
  申请人：L'OREAL

  公开号：US10918583B2

  公开（公告）日：2021-02-16

  The present invention relates to a cosmetic or dermatological composition comprising, in a physiologically acceptable support: a) at least one oily phase and b) at least one merocyanine compound of formula (1) defined hereinbelow and c) at least one organic UVB-screening agent chosen from: v) a liquid lipophilic organic UVB-screening agent vi) a hydrophilic organic UVB-screening agent vii) a triazine UVB-screening agent and viii) mixtures thereof; and d) at least one organic UVA-screening agent other than the said merocyanine compound; when the said UVB-screening agent is liquid and lipophilic, the said composition contains less than 2% by weight of cyclohexasiloxane relative to the total weight of the composition. Another subject of the present invention consists of a non-therapeutic cosmetic process for caring for and/or making up a keratin material, comprising the application, to the surface of the said keratin material, of at least one composition according to the invention as defined above. The invention also relates to a non-therapeutic cosmetic process for limiting the darkening of the skin and/or improving the colour and/or uniformity of the complexion, comprising the application, to the surface of the keratin material, of at least one composition as defined previously. The invention also relates to a non-therapeutic cosmetic process for preventing and/or treating the signs of ageing of a keratin material, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.

  本发明涉及一种化妆品或皮肤病组合物，其在生理上可接受的支持物中包含： a) 至少一种油性相和 b) 至少一种下文定义的式(1)美拉德花青化合物和 c) 至少一种有机 UVB 屏蔽剂，选自v) 液体亲脂性有机 UVB 增白剂 vi) 亲水性有机 UVB 增白剂 vii) 三嗪类 UVB 增白剂和 viii) 它们的混合物；和 d) 至少一种有机 UVA 增白剂，而不是上述美拉德花青化合物；当上述 UVB 增白剂为液态亲脂性时，上述组合物中环己基硅氧烷的含量小于组合物总重量的 2%（按重量计）。本发明的另一个主题是一种用于护理和/或妆点角蛋白材料的非治疗性化妆品工艺，包括在所述角蛋白材料表面涂抹至少一种根据上述定义的本发明的组合物。本发明还涉及一种用于限制皮肤变黑和/或改善肤色和/或肤色均匀度的非治疗性化妆品工艺，包括在角蛋白材料表面施用至少一种如前定义的本发明组合物。本发明还涉及一种用于预防和/或治疗角蛋白材料老化迹象的非治疗性化妆品工艺，包括在角蛋白材料表面涂抹至少一种如前定义的组合物。