1-[2-hydroxyethyl-(3-methoxybenzoyl)amino]-3-methyl-1-(4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[2-hydroxyethyl-(3-methoxybenzoyl)amino]-3-methyl-1-(4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)urea
• 化学式: C₂₄H₂₄N₆O₄
• 分子量: 460.5
• InChiKey: CUPMCCIGWIVKOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• SUBSTITUTED PYRROLOPYRIMIDINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Signal Pharmaceuticals, LLC

  公开号：EP2945636A2

  公开（公告）日：2015-11-25
• [EN] SUBSTITUTED PYRROLOPYRIMIDINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH<br/>[FR] COMPOSÉS DE TYPE PYRROLOPYRIMIDINE SUBSTITUÉE, COMPOSITIONS EN CONTENANT ET MÉTHODES DE TRAITEMENT FAISANT APPEL À EUX
  申请人：SIGNAL PHARM LLC

  公开号：WO2014113429A2

  公开（公告）日：2014-07-24

  Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.