N-(1-hydroxy-2-methyl-1-phenylpropan-2-yl)-1-phenylmethanimine oxide | 69295-30-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-hydroxy-2-methyl-1-phenylpropan-2-yl)-1-phenylmethanimine oxide
• CAS: 69295-30-3
• 化学式: C₁₇H₁₉NO₂
• 分子量: 269.343
• InChiKey: XBUQGZPNNVSPQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-hydroxy-2-methyl-1-phenylpropan-2-yl)-1-phenylmethanimine oxide 在 sodium hydride 作用下， 以 乙醚 为溶剂， 反应 1.17h， 生成
  参考文献：
  名称：

  Stable nitroxyl radicals with a hydrogen atom at ?-carbon atom of nitroxyl group

  摘要：

  Nitroxyl radicals containing the diphenylmethyl group as one of the substituents at the nitroxyl group are stable compounds that can be isolated in an individual state. N-(2-Hydroxy-3-methyl-2-phenylcyclohexyl)-N- diphenylmethylnitroxyl was characterized by X-ray diffraction analysis for the first time.

  DOI：

  10.1007/bf01433978
• 作为产物：
  描述：

  N-(2-hydroxy-1,1-dimethyl-2-phenylethyl)hydroxylamine 在 ammonium acetate 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 4.0h， 以30%的产率得到N-(1-hydroxy-2-methyl-1-phenylpropan-2-yl)-1-phenylmethanimine oxide
  参考文献：
  名称：

  乙酸铵作为空间位阻官能化羟胺与酮缩合的催化剂

  摘要：

  发现乙酸铵是 α-羟基氨基肟和 α-羟基氨基醇与酮缩合的催化剂。这种缩合导致空间位阻杂环羟胺，它是稳定的氮氧化合物的前体。

  DOI：

  10.1007/bf02502943

文献信息

• Synthesis of stable oxazolidine nitroxyl radicals with methoxy groups at the ?-carbon atoms to the radical site
  作者：S. M. Bakunova、I. A. Grigor'ev、I. A. Kirilyuk、Yu. V. Gatilov、I. Yu. Bagryanskaya、L. B. Volodarskii

  DOI：10.1007/bf01150905

  日期：1992.4

  The condensation of alpha-hydroxyaminoalcohols with aldehydes and acetone gave 3-hydroxyoxazolidines and tautomeric N-(2-hydroxyethyl)-alpha-arylnitrones, whose oxidation by PbO2 in methanol leads to stable oxazolidine nitroxyl radicals with methoxy groups at C2 and C4.
• Ammounium acetate as a catalyst of the condensation of sterically hindered functionalized hydroxylamines with ketones
  作者：V. A. Reznikov、L. B. Volodarsky

  DOI：10.1007/bf02502943

  日期：1997.9

  Ammonium acetate was found to be a catalyst of the condensation of α-hydroxylamino oximes and α-hydroxylamino alcohols with ketones. This condensation leads to sterically hindered heterocyclic hydroxylamines, which are precursors of stable nitroxides.

  发现乙酸铵是 α-羟基氨基肟和 α-羟基氨基醇与酮缩合的催化剂。这种缩合导致空间位阻杂环羟胺，它是稳定的氮氧化合物的前体。
• Stable nitroxyl radicals with a hydrogen atom at ?-carbon atom of nitroxyl group
  作者：V. A. Reznikov、I. A. Gulorov、Yu. V. Gatilov、T. V. Rybalova、L. B. Volodarsky

  DOI：10.1007/bf01433978

  日期：1996.2

  Nitroxyl radicals containing the diphenylmethyl group as one of the substituents at the nitroxyl group are stable compounds that can be isolated in an individual state. N-(2-Hydroxy-3-methyl-2-phenylcyclohexyl)-N- diphenylmethylnitroxyl was characterized by X-ray diffraction analysis for the first time.