2-hydroxy-3-m-toluidino-propane-1-sulfonic acid | 84061-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-3-m-toluidino-propane-1-sulfonic acid
• 英文别名: 2-Hydroxy-3-m-toluidino-propan-1-sulfonsaeure；2-Hydroxy-3-(3-methylanilino)propane-1-sulfonic acid
• CAS: 84061-71-2
• 化学式: C₁₀H₁₅NO₄S
• 分子量: 245.299
• InChiKey: RXXOXPGVDNVIKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  95
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氯-2-羟基丙烷磺酸 、 3-甲基苯胺 生成 2-hydroxy-3-m-toluidino-propane-1-sulfonic acid
  参考文献：
  名称：

  Tsunoo, Journal of Biochemistry, 1937, vol. 25, p. 375,377

  摘要：

  DOI：

文献信息

• Method for the determination of Leucine Aminopeptidase (LAP)
  申请人：Kyowa Medex Co. Ltd.

  公开号：EP0152274A2

  公开（公告）日：1985-08-21

  The present invention provides a method for the determination of leucine-aminopeptidase (hereinafter referred to as LAP) activity or Y-glutamyltranspeptidase (hereinafter referred to as γ-GTP) activity in a sample which comprises converting the substrate for the enzyme to be determined represented by the general formula (I): wherein Z represents (CH3)2CHCH2CH(NH2)-or(NH2)(COOH) CHCH2CH2-, R, represents hydrogen, alkyl or substituted alkyl, R2 represents alkylene or hydroxyalkylene, R3 and R4 are the same or different and represents hydrogen, halogeno, nitro, hydroxyl, sulfo, carboxyl, alkyl, and alkoxy, and salts thereof into the compound represented by the general formula (II): wherein R,, R2, R3 and R4 have the same meanings as defined above [hereinafter referred to as compound (II)] by the action of LAP or y-GTP, (a) reacting the compound (II) with a chromogen to form a pigment or (b) converting the compound (II)-into diazonium salt and reacting the diazonium salt with coupling agent to form azo dye, and measuring the absorption of the colored reaction solution.

  本发明提供了一种测定样品中亮氨酸-氨基肽酶（以下简称 LAP）活性或 Y-谷氨酰转肽酶（以下简称 γ-GTP）活性的方法，该方法包括将通式 (I) 所代表的待测定酶的底物转化： 其中 Z 代表(CH3)2CHCH2CH(NH2)-或(NH2)(COOH) CHCH2CH2-，R 代表氢、烷基或取代的烷基，R2 代表亚烷基或羟基亚烷基，R3 和 R4 相同或不同并代表氢、卤素、硝基、羟基、磺基、羧基、烷基和烷氧基，以及它们的盐： 其中 R、R2、R3 和 R4 的含义与上述定义相同[以下简称化合物（II）]，在 LAP 或 y-GTP 的作用下，(a) 使化合物（II）与发色剂反应生成色素，或 (b) 将化合物（II）转化为重氮盐，并使重氮盐与偶联剂反应生成偶氮染料，然后测量有色反应溶液的吸收率。
• COMPONENT MEASUREMENT SYSTEM, MEASUREMENT DEVICE, AND MEASUREMENT TIP
  申请人：Terumo Kabushiki Kaisha

  公开号：EP3722790A1

  公开（公告）日：2020-10-14

  A component measurement system (10) includes a measurement tip (12) capable of collecting blood, and a measurement device (14) that measures a blood glucose level of the blood collected by the measurement tip (12). The measurement tip (12) has a printing layer (18) disposed on a surface of a tip body (16) and indicating information relating to a spatial clearance (CL). The measurement device (14) has a reading unit (96) that reads the information relating to the spatial clearance (CL) from the printing layer (18), and a control unit (88) that calculates the blood glucose level, based on the spatial clearance (CL) read by the reading unit (96).

  组件测量系统 (10) 包括一个能够收集血液的测量尖端 (12) 和一个测量装置 (14)，后者用于测量测量尖端 (12) 所收集血液的血糖水平。测量尖端（12）有一个印刷层（18），设置在尖端主体（16）的表面上，并显示与空间间隙（CL）有关的信息。测量装置 (14) 具有读取单元 (96) 和控制单元 (88)，前者从打印层 (18) 中读取与空间间隙 (CL) 有关的信息，后者根据读取单元 (96) 读取的空间间隙 (CL) 计算血糖水平。
• COMPOSITIONS AND METHODS RELATED TO BACTERIAL EAP, EMP, AND/OR ADSA PROTEINS
  申请人：University Of Chicago

  公开号：EP2341929A1

  公开（公告）日：2011-07-13
• BIOMARKERS IN THE SELECTION OF THERAPY OF HEART FAILURE
  申请人：Roche Diagnostics GmbH

  公开号：EP2929354A1

  公开（公告）日：2015-10-14
• MODIFIED SARCOSINE OXIDASE, AND GENE AND PRODUCTION METHOD THEREFOR
  申请人：KIKKOMAN CORPORATION

  公开号：US20190218528A1

  公开（公告）日：2019-07-18

  To reduce the effect of L-proline in the reaction of a sarcosine oxidase. A modified sarcosine oxidase having reduced reactivity to L-proline is provided.