(2R,4S,5R)-5-ethyl-3-fluoro-3,4-dimethyloxolan-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: (2R,4S,5R)-5-ethyl-3-fluoro-3,4-dimethyloxolan-2-ol
• 化学式: C₈H₁₅FO₂
• 分子量: 162.2
• InChiKey: RZVIDMXIWKTOTB-FWYCZPIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PURINE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS
  申请人：Schinazi Raymond F.

  公开号：US20140212382A1

  公开（公告）日：2014-07-31

  The present invention is directed to compounds, compositions and methods for treating or preventing viral infections using nucleoside analog monophosphate prodrugs. More specifically, HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever in human patients or other animal hosts. The compounds are certain 2,6-diamino 2-C-methyl purine nucleoside monophosphate prodrugs and modified prodrug analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever. This invention teaches how to modify the metabolic pathway of 2,6-diamino 2′-C-methyl purine and deliver nucleotide triphosphate(s) to polymerases at heretofore unobtainable therapeutically-relevant concentrations.

  本发明涉及使用核苷类似物单磷酸前药治疗或预防病毒感染的化合物、组合物和方法。更具体地说，本发明适用于治疗人类患者或其他动物宿主的丙型肝炎病毒、诺如病毒、萨波罗病毒、登革热病毒、基孔肯雅病毒和黄热病等病毒感染。所述化合物是特定的2,6-二氨基2-C-甲基嘌呤核苷单磷酸前药和修饰的前药类似物，以及其药学上可接受的盐、前药和其他衍生物。特别地，所述化合物对丙型肝炎病毒、诺如病毒、萨波罗病毒、登革热病毒、基孔肯雅病毒和黄热病毒表现出强效的抗病毒活性。本发明教导如何修改2,6-二氨基2'-C-甲基嘌呤的代谢途径，并以迄今为止无法获得的治疗相关浓度向聚合酶提供核苷酸三磷酸。
• NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
  申请人：EMORY UNIVERSITY

  公开号：US20160220595A1

  公开（公告）日：2016-08-04

  This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

  本公开涉及含有至少一种硫醇、硫酮或硫醚的核苷酸和核苷治疗组合物及其在治疗传染病、病毒感染和癌症方面的用途。