1-Benzyl-3-(2-oxo-1,3-dihydrobenzimidazol-5-yl)thiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-Benzyl-3-(2-oxo-1,3-dihydrobenzimidazol-5-yl)thiourea
• 化学式: C₁₅H₁₄N₄OS
• 分子量: 298.4
• InChiKey: FYWAUYOJEICEFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  97.3
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• SMALL MOLECULE GRB2 STABILIZERS FOR RAS MAP KINASE INHIBITION
  申请人：Board of Regents, The University of Texas System

  公开号：US20220151991A1

  公开（公告）日：2022-05-19

  The present disclosure compounds of the formula (I-A) or (I), wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer. The present disclosure also provides methods for the use of compounds of the formula (III), wherein the variables are defined herein.