N-amino-4-chloro-N'-phenylbenzenecarboximidamide | 136169-38-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-amino-4-chloro-N'-phenylbenzenecarboximidamide
• CAS: 136169-38-5
• 化学式: C₁₃H₁₂ClN₃
• 分子量: 245.711
• InChiKey: DFICZFZAUJDXHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-amino-4-chloro-N'-phenylbenzenecarboximidamide 、 异氰酸苯酯 以 氯仿 为溶剂， 以46%的产率得到1-[[C-(4-chlorophenyl)-N-phenylcarbonimidoyl]amino]-3-phenylurea
  参考文献：
  名称：

  Synthesis and cytotoxic activity on islets of Langerhans of benzamide thiosemicarbazone derivatives

  摘要：

  Eleven 1-(4-substituted alpha-arylaminobenzylidene)thiosemicarbazides 1 and the related semicarbazones 2 were synthesized and tested in vitro for their inhibitory effects on the islets of Langerhans. Only the thiosemicarbazones 1 suppressed the insulin and glucagon secretions while the somatostatin release persisted. The 1-(alpha-anilino-4-methylbenzylidene)thiosemicarbazide 1f was the most potent suppressor of insulin release and lysed the islet beta cells. Zinc sulfate protected islets from the suppressive and toxic effects of 1f. These compounds 1 could be potential drugs for the treatment of insulinomas.

  DOI：

  10.1016/0223-5234(91)90059-v
• 作为产物：
  描述：

  4-氯硫代苯甲酰苯胺 在 一水合肼 作用下， 以63%的产率得到N-amino-4-chloro-N'-phenylbenzenecarboximidamide
  参考文献：
  名称：

  Synthesis and cytotoxic activity on islets of Langerhans of benzamide thiosemicarbazone derivatives

  摘要：

  Eleven 1-(4-substituted alpha-arylaminobenzylidene)thiosemicarbazides 1 and the related semicarbazones 2 were synthesized and tested in vitro for their inhibitory effects on the islets of Langerhans. Only the thiosemicarbazones 1 suppressed the insulin and glucagon secretions while the somatostatin release persisted. The 1-(alpha-anilino-4-methylbenzylidene)thiosemicarbazide 1f was the most potent suppressor of insulin release and lysed the islet beta cells. Zinc sulfate protected islets from the suppressive and toxic effects of 1f. These compounds 1 could be potential drugs for the treatment of insulinomas.

  DOI：

  10.1016/0223-5234(91)90059-v

文献信息

• Synthesis and cytotoxic activity on islets of Langerhans of benzamide thiosemicarbazone derivatives
  作者：M Campana、C Laborie、G Barbier、R Assan、R Milcent

  DOI：10.1016/0223-5234(91)90059-v

  日期：1991.4

  Eleven 1-(4-substituted alpha-arylaminobenzylidene)thiosemicarbazides 1 and the related semicarbazones 2 were synthesized and tested in vitro for their inhibitory effects on the islets of Langerhans. Only the thiosemicarbazones 1 suppressed the insulin and glucagon secretions while the somatostatin release persisted. The 1-(alpha-anilino-4-methylbenzylidene)thiosemicarbazide 1f was the most potent suppressor of insulin release and lysed the islet beta cells. Zinc sulfate protected islets from the suppressive and toxic effects of 1f. These compounds 1 could be potential drugs for the treatment of insulinomas.