2,6-Bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-butylphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-Bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-butylphenol
• 英文别名: 2,6-bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-butylphenol
• 化学式: C₃₆H₄₀N₆O
• 分子量: 572.753
• InChiKey: DOTCCRQVJHFTGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  43
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  zinc(II) nitrate hexahydrate 、 2,6-Bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-butylphenol 以 甲醇 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes

  摘要：

  This study measured the antiplasmodial activity of nine zinc-dipicolylamine (ZnDPA) complexes against three strains of Plasmodium falciparum, the causative parasite of malaria. Growth inhibition assays showed significant activity against all tested strains, with 50% inhibitory concentrations between 5 and 600 nM and almost no toxic effect against host cells including healthy red blood cells. Fluorescence microscopy studies with a green-fluorescent ZnDPA probe showed selective targeting of infected red blood cells. The results suggest that ZnDPA coordination complexes are promising antiplasmodial agents with potential for targeted malaria treatment. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2017.03.050
• 作为产物：
  描述：

  聚合甲醛 、 4-丁基苯酚 、 二甲基吡啶胺 以 乙醇 、 水 为溶剂， 反应 48.0h， 以72%的产率得到2,6-Bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-butylphenol
  参考文献：
  名称：

  Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes

  摘要：

  This study measured the antiplasmodial activity of nine zinc-dipicolylamine (ZnDPA) complexes against three strains of Plasmodium falciparum, the causative parasite of malaria. Growth inhibition assays showed significant activity against all tested strains, with 50% inhibitory concentrations between 5 and 600 nM and almost no toxic effect against host cells including healthy red blood cells. Fluorescence microscopy studies with a green-fluorescent ZnDPA probe showed selective targeting of infected red blood cells. The results suggest that ZnDPA coordination complexes are promising antiplasmodial agents with potential for targeted malaria treatment. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2017.03.050

文献信息

• [EN] MAGNETIC SEPARATION USING NANOPARTICLES<br/>[FR] SÉPARATION MAGNÉTIQUE À L'AIDE DE NANOPARTICULES
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2014120794A1

  公开（公告）日：2014-08-07

  Nanoparticles as described herein are configured to bind to bacterial contaminants, such as Gram positive bacteria, Gram negative bacteria, and endotoxins. The nanoparticles include a core comprising a magnetic material; and a plurality of ligands attached to the core. The ligands include, for example, bis(dipicolylamine) ("DPA") coordinated with a metal ion, e.g., Zn2+ or Cu2+, to form, e.g., bis-Zn-DPA or bis-Cu-DPA, which can bind to the bacterial contaminants. The nanoparticles can be included in compositions for use in methods and systems to separate bacterial contaminants from liquids, such as liquids, such as blood, e.g., whole or diluted blood, buffer solutions, albumin solutions, beverages for human and/or animal consumption, e.g., drinking water, liquid medications for humans and/or animals, or other liquids.