2-methyl-3-(phenylthio)-6-tosylpyridin-4-ol | 1103495-01-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-methyl-3-(phenylthio)-6-tosylpyridin-4-ol
• 英文别名: 2-methyl-6-(4-methylphenyl)sulfonyl-3-phenylsulfanyl-1H-pyridin-4-one
• CAS: 1103495-01-7
• 化学式: C₁₉H₁₇NO₃S₂
• 分子量: 371.481
• InChiKey: QDXNNZJHLNQYRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  96.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-甲苯磺酰氰 、 2,4-bis(trimethylsilyloxy)-3-phenylthio-1,3-pentadiene 在 水 、 氯化铵 作用下， 以64%的产率得到2-methyl-3-(phenylthio)-6-tosylpyridin-4-ol
  参考文献：
  名称：

  Hetero-Diels–Alder reaction of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with arylsulfonylcyanides. Synthesis and antimicrobial activity of 4-hydroxy-2-(arylsulfonyl)pyridines

  摘要：

  Hetero-Diels-Alder reactions of 1,3-bis(silyloxy)-1,3-butadienes with arylsulfonylcyanides afforded a variety of 4-hydroxy-2-(arylsulfonyl) pyridines. Several derivatives show antimicrobial activity against Gram-positive bacteria. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.10.033

文献信息

• Hetero-Diels–Alder reaction of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with arylsulfonylcyanides. Synthesis and antimicrobial activity of 4-hydroxy-2-(arylsulfonyl)pyridines
  作者：Ibrar Hussain、Mirza Arfan Yawer、Michael Lalk、Ulrike Lindequist、Alexander Villinger、Christine Fischer、Peter Langer

  DOI：10.1016/j.bmc.2008.10.033

  日期：2008.12

  Hetero-Diels-Alder reactions of 1,3-bis(silyloxy)-1,3-butadienes with arylsulfonylcyanides afforded a variety of 4-hydroxy-2-(arylsulfonyl) pyridines. Several derivatives show antimicrobial activity against Gram-positive bacteria. (c) 2008 Elsevier Ltd. All rights reserved.