5-(Difluoromethoxy)-2-methylpyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(Difluoromethoxy)-2-methylpyrimidine
• 英文别名: 5-(difluoromethoxy)-2-methylpyrimidine
• 化学式: C₆H₆F₂N₂O
• 分子量: 160.12
• InChiKey: UJZNPCHGRYNWCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2,3,4,5-TÉTRAHYDROPYRIDINE-6-AMINE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2017050978A1

  公开（公告）日：2017-03-30

  The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine compound inhibitors of beta-secretase having the structure shown in Formula (I) wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, or dementia associated with beta-amyloid.

  本发明涉及具有如公式(I)所示结构的β-分泌酶抑制剂2,3,4,5-四氢吡啶-6-胺化合物，其中基团如规范中所定义。该发明还涉及包括这些化合物的药物组合物，用于制备这些化合物和组合物的方法，以及利用这些化合物和组合物预防和治疗涉及β-分泌酶的疾病，如阿尔茨海默病（AD）、轻度认知障碍、老年痴呆、带有Lewy小体的痴呆、唐氏综合征、与中风相关的痴呆、与帕金森病相关的痴呆或与β-淀粉样蛋白相关的痴呆。
• [EN] HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES POUR LA LUTTE CONTRE LES NUISIBLES INVERTÉBRÉS
  申请人：BASF SE

  公开号：WO2021228594A1

  公开（公告）日：2021-11-18

  The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.

  该发明涉及公式（I）中的化合物，其中变量的含义如规范中定义的，包括包含它们的组合物，包含它们的活性化合物组合物，以及它们用于保护生长中的植物和动物免受无脊椎动物害虫攻击或侵害的用途，此外，还涉及包含这种化合物的种子。
• Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20140221377A1

  公开（公告）日：2014-08-07

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  该披露提供了I式化合物及其盐，以及使用这些化合物的组合物和方法。这些化合物是尼古丁酸α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。
• QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150094309A1

  公开（公告）日：2015-04-02

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  本公开提供I式化合物及其盐，以及使用该化合物的组合物和方法。该化合物是尼古丁α7受体的配体，可用于治疗中枢神经系统的各种障碍，特别是情感和神经退行性障碍。
• 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP3353163B1

  公开（公告）日：2020-02-05