3-[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]-7,8-dimethoxy-5-methyl-2,5-dihydro-1H-3-benzazepin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 3-[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]-7,8-dimethoxy-5-methyl-2,5-dihydro-1H-3-benzazepin-4-one
• 化学式: C₂₈H₃₈N₂O₅
• 分子量: 482.6
• InChiKey: SEVJCAPIDKDBNR-BPARTEKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  60.5
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• KIT-OF-PARTS
  申请人：FOLGER Martin

  公开号：US20140224680A1

  公开（公告）日：2014-08-14

  The present invention relates to a kit-of-parts, comprising A) a packaging ( 5 ), containing a defined amount of a pharmaceutically active ingredient in the form of solid coated one or multi-layered particles; B) a container ( 10 ), comprising a liquid oily composition to disperse or suspend the solid coated one or multi-layered particles contained in A); C) a dispenser ( 20 ); D) an adapter ( 50 ), having an application arrangement piece ( 55 ) with a through-hole ( 57 ) to fit the dispenser ( 20 ) to the container ( 10 ) of B); and E) instructions for use of the kit. The user just needs to mix and shake the components in order to produce a stable homogeneous mixture, which is: suited for exact dosing; stable and reusable; convenient to use; safe for the user due to omittance of needles; and has no injury risk for the user.
• TASTE MASKED PHARMACEUTICAL COMPOSITION
  申请人：FOLGER Martin

  公开号：US20140227351A1

  公开（公告）日：2014-08-14

  Taste masked multi-layered particles include an inert core, one or more coating layer(s) comprising a pharmaceutically active ingredient and a binder, an intermediate coating layer (seal coating) free from a low molecular weight water-soluble ionic compound and including a water-soluble pharmaceutical film-forming compound selected from (i) HPMC and PEG or (ii) PVP, and an outer coating layer (final or taste masking coating) free from a low molecular weight water-soluble ionic compound and comprising (i) a poly(meth)acrylate or (ii) a mixture including 60-90% (w/w) EC and 10-40% (w/w) HPMC, where the pharmaceutically active ingredient is water-soluble and includes either at least one basic group and/or a bitter taste. Further disclosed are methods for the production of such particles and pharmaceutical compositions including such particles.
• US9289390B2
  申请人：——

  公开号：US9289390B2

  公开（公告）日：2016-03-22