5-[[5-[2-[2-[3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethylperoxy]ethyl]-4-methyl-1,3-thiazol-3-ium-3-yl]methyl]-2-methylpyrimidin-4-amine;hydrate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-[[5-[2-[2-[3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethylperoxy]ethyl]-4-methyl-1,3-thiazol-3-ium-3-yl]methyl]-2-methylpyrimidin-4-amine;hydrate
• 英文别名: 5-[[5-[2-[2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethylperoxy]ethyl]-4-methyl-1,3-thiazol-3-ium-3-yl]methyl]-2-methylpyrimidin-4-amine;hydrate
• 化学式: C24H34N8O3S2+2
• 分子量: 546.7
• InChiKey: JZONWNPSMDMFLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  187
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• PROTECTANT FOR ELECTRON MICROSCOPE OBSERVATION OF HYDRATED BIOLOGICAL SAMPLE, KIT FOR ELECTRON MICROSCOPE OBSERVATION, METHOD FOR OBSERVATION, DIAGNOSIS, EVALUATION, OR QUANTIFICATION BY ELECTRON MICROSCOPE, AND SAMPLE STAGE
  申请人：Japan Science and Technology Agency

  公开号：EP3101407A1

  公开（公告）日：2016-12-07

  Provided are a protective agent for electron microscopic observation in a vacuum which can protect a biological sample in a water-containing state, such as a mammal, a plant tissue or a cultured cell, and a single cell in the living state without deforming it even in a vacuum, a kit using the same, methods for observation, diagnosis, evaluation, and quantification of a sample by an electron microscope, and a sample stage to be used for the observation. The protective agent for electron microscopic observation of the present invention contains a survival environment imparting component, a saccharide, and an electrolyte.

  本发明提供了一种用于在真空中进行电子显微镜观察的保护剂，它可以保护含水状态下的生物样品，如哺乳动物、植物组织或培养细胞，以及活体状态下的单细胞，即使在真空中也不会使其变形；还提供了一种使用该保护剂的试剂盒、一种用电子显微镜对样品进行观察、诊断、评估和定量的方法，以及一种用于观察的样品台。本发明的用于电子显微镜观察的保护剂含有生存环境赋予成分、糖类和电解质。
• Protective agent for electron microscopic observation of biological sample in water-containing state, kit for electron microscopic observation, methods for observation, diagnosis, evaluation, and quantification by electron microscope, and sample stage
  申请人：JAPAN SCIENCE AND TECHNOLOGY AGENCY

  公开号：US10128078B2

  公开（公告）日：2018-11-13

  Provided are a protective agent for electron microscopic observation in a vacuum which can protect a biological sample in a water-containing state, such as a mammal, a plant tissue or a cultured cell, and a single cell in the living state without deforming it even in a vacuum, a kit using the same, methods for observation, diagnosis, evaluation, and quantification of a sample by an electron microscope, and a sample stage to be used for the observation. The protective agent for electron microscopic observation of the present invention contains a a component to impart the survival environment, a saccharide, and an electrolyte.

  本发明提供了一种用于在真空中进行电子显微镜观察的保护剂，该保护剂可以保护含水状态下的生物样品，如哺乳动物、植物组织或培养细胞，以及活体状态下的单细胞，即使在真空中也不会使其变形；还提供了使用该保护剂的试剂盒、通过电子显微镜对样品进行观察、诊断、评估和定量的方法，以及用于观察的样品台。本发明用于电子显微镜观察的保护剂含有一种赋予生存环境的成分、一种糖类和一种电解质。
• ELECTRON-MICROSCOPIC EXAMINATION METHOD FOR EXAMINING A LIVING BIOLOGICAL SAMPLE
  申请人：Japan Science and Technology Agency

  公开号：EP2755225B1

  公开（公告）日：2017-05-10
• ELECTRON MICROSCOPIC OBSERVATION METHOD FOR OBSERVING BIOLOGICAL SAMPLE IN SHAPE AS IT IS, AND COMPOSITION FOR EVAPORATION SUPPRESSION UNDER VACUUM, SCANNING ELECTRON MICROSCOPE, AND TRANSMISSION ELECTRON MICROSCOPE USED IN THE METHOD
  申请人：JAPAN SCIENCE AND TECHNOLOGY AGENCY

  公开号：US20140227734A1

  公开（公告）日：2014-08-14

  Provided is an observation method by an electron microscope, in which a biological sample can be observed as it is alive and a situation that the biological sample is moving can be observed using an electron microscope, and a composition for evaporation suppression under vacuum, a scanning electron microscope, and a transmission electron microscope used in the method. The sample observation method by an electron microscope according to the invention includes applying a composition for evaporation suppression containing at least one kind selected from an amphiphilic compound, oils and fats, and an ionic liquid to the surface of a sample to form a thin film, and covering the sample with the thin film, and displaying an electron microscopic image of the sample, which is covered with the thin film and accommodated in a sample chamber under vacuum, on a display device.
• PROTECTIVE AGENT FOR ELECTRON MICROSCOPIC OBSERVATION OF BIOLOGICAL SAMPLE IN WATER-CONTAINING STATE, KIT FOR ELECTRON MICROSCOPIC OBSERVATION, METHODS FOR OBSERVATION, DIAGNOSIS, EVALUATION, AND QUANTIFICATION BY ELECTRON MICROSCOPE, AND SAMPLE STAGE
  申请人：JAPAN SCIENCE AND TECHNOLOGY AGENCY

  公开号：US20160343539A1

  公开（公告）日：2016-11-24

  Provided are a protective agent for electron microscopic observation in a vacuum which can protect a biological sample in a water-containing state, such as a mammal, a plant tissue or a cultured cell, and a single cell in the living state without deforming it even in a vacuum, a kit using the same, methods for observation, diagnosis, evaluation, and quantification of a sample by an electron microscope, and a sample stage to be used for the observation. The protective agent for electron microscopic observation of the present invention contains a a component to impart the survival environment, a saccharide, and an electrolyte.