methyl 2-[amino(4-chloropyridin-2-yl)methylene]-1-methylhydrazinecarbodithiolate | 1192456-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl 2-[amino(4-chloropyridin-2-yl)methylene]-1-methylhydrazinecarbodithiolate
• 英文别名: methyl N-[(E)-[amino-(4-chloropyridin-2-yl)methylidene]amino]-N-methylcarbamodithioate
• CAS: 1192456-40-8
• 化学式: C₉H₁₁ClN₄S₂
• 分子量: 274.798
• InChiKey: TWYPYUJGDTYZOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二硫化碳 、 4-chloro-N'-methylpicolinohydrazonamide 、 碘甲烷 在 三乙胺 作用下， 以 1,1-二氟四氯乙烷 为溶剂， 反应 2.5h， 以28%的产率得到methyl 2-[amino(4-chloropyridin-2-yl)methylene]-1-methylhydrazinecarbodithiolate
  参考文献：
  名称：

  The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives

  摘要：

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from

  DOI：

  10.3987/com-09-11696

文献信息

• The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives
  作者：Agnieszka Bogdanowicz、Henryk Foks、Anna Kędzia、Ewa Kwapisz、Zofia Zwolska、Ewa Augustynowicz-Kopeć

  DOI：10.3987/com-09-11696

  日期：——

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from