1-(2-Oxo-1,3-dihydrobenzimidazol-5-yl)-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(2-Oxo-1,3-dihydrobenzimidazol-5-yl)-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea
• 化学式: C₂₀H₂₂N₄O₂
• 分子量: 350.4
• InChiKey: KFXJZDILTSMDFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections
  申请人：Hedstrom Lizbeth K.

  公开号：US20120101096A1

  公开（公告）日：2012-04-26

  Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.

  本文描述了一些化合物，以及其药用盐和前药，这些化合物可用作IMPDH的抑制剂。在某些实施例中，本发明的化合物选择性地抑制寄生物IMPDH而不抑制宿主IMPDH。此外，本发明提供了包含一种或多种本发明化合物的药物组合物。本发明还涉及治疗哺乳动物中各种寄生虫和细菌感染的方法。此外，这些化合物可以单独使用或与其他治疗或预防剂（如抗病毒药物、抗炎药物、抗微生物药物和免疫抑制剂）结合使用。
• INK COMPOSITION AND IMAGE RECORDING METHOD AND IMAGE RECORDED MATTER USING SAME
  申请人：SHIMOHARA Norihide

  公开号：US20080241485A1

  公开（公告）日：2008-10-02

  An ink composition containing at least a polymerizable composition, a pigment, and a polymer represented by General Formula (1): where R 1 represents an (m+n)-valent organic linking group, R 2 represents a single bond or divalent organic linking group; A 1 represents a monovalent organic group having a pigment adsorption structure that contains at least one selected from organic pigment structure, heterocyclic structure, acidic group, group having a basic nitrogen atom, urea group, urethane group, group having a coordinating oxygen atom, hydrocarbon group having 4 or more carbon atoms, alkoxysilyl group, epoxy group, isocyanate group, and hydroxyl group; the n groups A 1 and bonds or groups R 2 may independently be the same or different; “m” is 1 to 8, “n” is 2 to 9, and m+n is 3 to 10; P 1 represents a polymer skeleton; and the m skeletons P 1 may be the same or different.
• METHOD OF PRODUCING ORGANIC NANOPARTICLES, ORGANIC NANOPARTICLES THUS OBTAINED, INKJET INK FOR COLOR FILTER, COLORED PHOTOSENSITIVE RESIN COMPOSITION AND PHOTOSENSITIVE RESIN TRANSFER MATERIAL, CONTAINING THE SAME, AND COLOR FILTER, LIQUID CRYSTAL DISPLAY DEVICE AND CCD DEVICE, PREPARED USING THE SAME
  申请人：Matsumoto Keisuke

  公开号：US20090059138A1

  公开（公告）日：2009-03-05

  A method of producing organic nanoparticles, comprising: mixing a solution of an organic material dissolved in a good solvent with a solvent that is compatible with the good solvent but is a poor solvent for the organic material, to prepare a dispersion in which the organic material is being formed to organic fine particles of a size in the order of nanometer; wherein the dispersion contains a polymer compound having a weight-average molecular weight of 1,000 or more represented by the following formula (1): wherein R 1 represents a (m+n)-valent connecting group; R 2 represents a single bond or a divalent connecting group; A 1 represents a specific monovalent organic group; when n is two or more, plural A 1 s may be the same or different; m represents 1 to 8; n represents 2 to 9; m+n is 3 to 10; and P 1 represents a polymer compound residue.
• PROCESSED PIGMENT, PIGMENT-DISPERSED COMPOSITION, COLORED PHOTOSENSITIVE COMPOSITION, COLOR FILTER, LIQUID CRYSTAL DISPLAY ELEMENT, AND SOLID IMAGE PICKUP ELEMENT
  申请人：FUJIMAKI Kazuhiro

  公开号：US20090068575A1

  公开（公告）日：2009-03-12

  Provided are a processed pigment excellent in dispersibility and dispersion stability, a pigment-dispersed composition excellent in dispersibility and dispersion stability of a pigment that uses the processed pigment, a colored photosensitive composition using the pigment-dispersed composition, and a color filter having improved color properties that uses the colored photosensitive composition, in which a pigment is covered with at least one of a specific polymer compound selected from the following (SP-1) to (SP-3); (SP-1) A polymer compound having a heterocycle on a side chain, (SP-2) A graft polymer compound having a weight average molecular weight of from 1,000 to 100000, (SP-3) A polymer compound represented by the following formula (3-1), wherein, R C , R D , A 1 and P 1 respectively represent an organic linkage group, a single bond or a divalent organic linkage group, a monovalent organic group containing such as an organic dye structure, and a polymer skeleton.
• INKJET INK COMPOSITION, AND INKJET RECORDING METHOD AND PRINTED MATERIAL EMPLOYING SAME
  申请人：KASAI Seishi

  公开号：US20090214797A1

  公开（公告）日：2009-08-27

  An inkjet ink composition is provided that includes at least one type of organic pigment exhibiting an orange, violet, or green color, at least one type selected from the group consisting of polymer compounds derived from a monomer represented by specific Formulae and a polymer represented by a specific Formula, and an actinic radiation-curable compound.