N-[2-[(4R)-2-amino-5-methoxy-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]pyridin-4-yl]-5-(fluoromethyl)pyrazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[2-[(4R)-2-amino-5-methoxy-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]pyridin-4-yl]-5-(fluoromethyl)pyrazine-2-carboxamide
• 化学式: C₁₇H₁₉FN₆O₂S
• 分子量: 390.4
• InChiKey: DWWRGGBNUYQAJI-FBMWCMRBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  141
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• PYRIDINE DERIVATIVES AND A PHARMACEUTICAL COMPOSITION FOR INHIBITING BACE1 CONTAINING THEM
  申请人：Tada Yukio

  公开号：US20140235626A1

  公开（公告）日：2014-08-21

  The present invention provides a compound of formula (I): wherein ring B is substituted or unsubstituted carbocycle or heterocycle, R 1 is substituted or unsubstituted alkyl or the like, R 2a and R 2b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R 3 , R 4a and R 4b are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, a dashed line represents a presence or absence of a bond, R 5 is hydrogen, substituted or unsubstituted alkyl or the like, R 6 is halogen, hydroxy, substituted or unsubstituted alkyl or the like, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid β production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins.