1H-pyrazole;pyrimidin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1H-pyrazole;pyrimidin-2-amine
• 化学式: C7H9N5
• 分子量: 163.18
• InChiKey: JOOFEGKZJOFZKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.47
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NOVEL RAF KINASE INHIBITORS
  申请人：Jean-Michel VERNIER

  公开号：US20150232452A1

  公开（公告）日：2015-08-20

  Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinase mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.

  本文描述了一些化合物、药物组合物和方法，用于抑制RAF激酶介导的信号传导。这些化合物、药物组合物和方法在治疗人类疾病和障碍方面具有用途。
• Treatment or prevention of an intestinal disease or disorder
  申请人：The United States of America, as represented by the Secretary, Department of Health & Human Services

  公开号：US10058559B2

  公开（公告）日：2018-08-28

  Disclosed are methods of treating or preventing an intestinal disease or disorder comprising administering to a subject a modulator of leucine rich repeat kinase 2 (LRRK2) in an amount effective to treat or prevent an intestinal disease or disorder and methods of determining the susceptibility or risk of a subject to develop an intestinal disease.

  所公开的是治疗或预防肠道疾病或紊乱的方法，包括向受试者施用有效量的富亮氨酸重复激酶 2 (LRRK2) 调节剂以治疗或预防肠道疾病或紊乱，以及确定受试者患肠道疾病的易感性或风险的方法。
• TREATMENT OR PREVENTION OF AN INTESTINAL DISEASE OR DISORDER
  申请人：The United States of America, as represented by the Secretary, Department of Health & Human Servic

  公开号：US20170079987A1

  公开（公告）日：2017-03-23

  Disclosed are methods of treating or preventing an intestinal disease or disorder comprising administering to a subject a modulator of leucine rich repeat kinase 2 (LRRK2) in an amount effective to treat or prevent an intestinal disease or disorder and methods of determining the susceptibility or risk of a subject to develop an intestinal disease.
• US8815882B2
  申请人：——

  公开号：US8815882B2

  公开（公告）日：2014-08-26
• US9212173B2
  申请人：——

  公开号：US9212173B2

  公开（公告）日：2015-12-15