1-[(2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-methylpyrimidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[(2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-methylpyrimidin-2-one
• 化学式: C10H12FN5O4
• 分子量: 285.23
• InChiKey: PKOUFPOTBSQQKT-IBCQBUCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  96.7
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 4'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF EBOLA VIRUS RNA REPLICATION
  申请人：Riboscience LLC

  公开号：US20160237106A1

  公开（公告）日：2016-08-18

  The application discloses compounds of Formula I wherein the variable substituents are as defined herein. The compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I are useful for the treatment of diseases mediated by Filoviruses such as Ebolavirus.

  该申请公开了一种公式I的化合物，其中变量取代基如本文所定义。公式I的化合物和包括公式I化合物的药物组合物对于治疗由埃博拉病毒等丝状病毒介导的疾病是有用的。
• SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
  申请人：Alios BioPharma, Inc.

  公开号：US20150011497A1

  公开（公告）日：2015-01-08

  Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a norovirus, with a nucleoside, a nucleotide and an analog thereof.

  本文披露了核苷、核苷酸及其类似物、包括一个或多个核苷、核苷酸及其类似物的药物组合物以及其合成方法。本文还披露了使用核苷、核苷酸和其类似物来改善和/或治疗疾病和/或病况，包括由诺如病毒引起的感染的方法。
• AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS
  申请人：Alios BioPharma, Inc.

  公开号：US20160264610A1

  公开（公告）日：2016-09-15

  Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

  本文披露了核苷、核苷酸及其类似物、包含一个或多个核苷、核苷酸及其类似物的制药组合物，以及它们的合成方法。本文还披露了使用核苷、核苷酸和其类似物改善和/或治疗疾病和/或病况的方法，包括来自副黏病毒和/或正黏病毒的感染。病毒感染的例子包括呼吸道合胞病毒（RSV）和流感感染。
• 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS
  申请人：Gilead Sciences, Inc.

  公开号：US20140235563A1

  公开（公告）日：2014-08-21

  Embodiments of the invention are to compounds, methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention are 2′,4′-substituted nucleoside compounds useful for the treatment of viral infections, such as HIV, HCV, and HBV infections.
• US9296777B2
  申请人：——

  公开号：US9296777B2

  公开（公告）日：2016-03-29