N-[3-[2,3-bis(2-methoxyethoxy)propoxy]propyl]-3-[3-[(2R)-2-(methylamino)-3-oxobutyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: N-[3-[2,3-bis(2-methoxyethoxy)propoxy]propyl]-3-[3-[(2R)-2-(methylamino)-3-oxobutyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]propanamide
• 化学式: C₂₄H₄₃N₃O₉S
• 分子量: 549.7
• InChiKey: VWWXVHHZJOISOR-KBWCOIMZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  37
• 可旋转键数：
  23
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  167
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Analogues of glucose-dependent insulinotropic polypeptide (GIP) modified at N-terminal
  申请人：IPSEN PHARMA S.A.S.

  公开号：EP2769986A2

  公开（公告）日：2014-08-27

  There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide, pharmaceutical compositions containing said compounds, and the use of said compounds as GIP-receptor agonists or antagonists for treatment of GIP-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity.

  本发明提供了一系列新型的葡萄糖依赖性促胰岛素多肽类似物、含有所述化合物的药物组合物，以及所述化合物作为 GIP 受体激动剂或拮抗剂用于治疗 GIP 受体介导的疾病，如非胰岛素依赖型糖尿病和肥胖症。
• ANALOGUES OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) MODIFIED AT N-TERMINAL
  申请人：IPSEN PHARMA S.A.S.

  公开号：US20150175665A1

  公开（公告）日：2015-06-25

  There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide, pharmaceutical compositions containing said compounds, and the use of said compounds as GIP-receptor agonists or antagonists for treatment of GIP-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity.
• GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGUES
  申请人：Ipsen Pharma S.A.S.

  公开号：US20150252093A1

  公开（公告）日：2015-09-10

  There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide compounds, pharmaceutical compositions containing said compounds, and the use of said compounds as GIP-receptor agonists or antagonists for treatment of GIP-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity.
• ANALOGUES OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE
  申请人：IPSEN PHARMA S.A.S.

  公开号：US20150252092A1

  公开（公告）日：2015-09-10

  There is provided a series of glucose-dependent insulinotropic polypeptide analog compounds, pharmaceutical compositions, and the use of the GIP polypeptide analog compounds as GIP-receptor agonists or antagonists for the treatment of GIP-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity.