[(2S,4S,5R)-4-[ethyl(hydroxy)phosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [(2S,4S,5R)-4-[ethyl(hydroxy)phosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C₁₂H₂₀N₂O₉P₂S
• 分子量: 430.31
• InChiKey: MUZIKWKSZVDRRV-QOWCAEACSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  187
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Short interfering nucleic acid (siNA) molecules containing a 2′ internucleoside linkage (3dT)
  申请人：SIRNA THERAPEUTICS, INC.

  公开号：US10738308B2

  公开（公告）日：2020-08-11

  The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5′ modified nucleotides that comprise, among other potential modifications, a 2′ internucleoside linkage. The invention further relates to 5′ modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.

  本发明涉及RNAi分子及其组合物，其包含连接反义链5′端的1位核苷酸和2位核苷酸的2′核苷间连接。具体地说，本发明涉及能够介导 RNA 干扰的单链和双链短干扰核酸（siNA）分子，这些分子包含 5′修饰的核苷酸，这些核苷酸除其他可能的修饰外，还包含 2′核苷间连接。本发明进一步涉及用作试剂生成本发明 RNAi 分子的 5′修饰核苷酸以及使用所公开 RNAi 分子的方法。
• SHORT INTERFERING NUCLEIC ACID (SINA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE
  申请人：Sirna Therapeutics, Inc.

  公开号：EP2958998B1

  公开（公告）日：2017-12-27
• [EN] SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE<br/>[FR] MOLÉCULES D'ACIDE NUCLÉIQUE INTERFÉRENT COURT (ANSI) CONTENANT UN ENCHAÎNEMENT INTERNUCLÉOSIDE 2'
  申请人：SIRNA THERAPEUTICS INC

  公开号：WO2014130607A1

  公开（公告）日：2014-08-28

  The present invention relates to RNAi molecules, and compositions thereof, comprising a 2' internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5' end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5' modified nucleotides that comprise, among other potential modifications, a 2' internucleoside linkage. The invention further relates to 5' modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.