1-(5-Chloropyrimidin-2-yl)-1-sulfanylurea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(5-Chloropyrimidin-2-yl)-1-sulfanylurea
• 英文别名: 1-(5-chloropyrimidin-2-yl)-1-sulfanylurea
• 化学式: C₅H₅ClN₄OS
• 分子量: 204.64
• InChiKey: VBKISRXRXTXKIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.1
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION
  申请人：The Institute for Hepatitis and Virus Research

  公开号：US20140249154A1

  公开（公告）日：2014-09-04

  Pharmaceutical compositions of the invention are presented which comprise substituted aminothiazoles derivatives. The substituted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unregulated cell growth. Such diseases include cancers such as hepatocellular carcinoma, and viral infections from a hepatitis virus.

  本发明提供了包含取代氨基噻唑衍生物的药物组合物。这些取代氨基噻唑衍生物在治疗与不受调控的细胞生长相关的疾病方面具有疾病修饰作用。这些疾病包括肝细胞癌以及由乙型肝炎病毒引起的病毒感染。
• Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication
  申请人：BARUCH S. BLUMBERG INSTITUTE

  公开号：US10087173B2

  公开（公告）日：2018-10-02

  Pharmaceutical compositions of the invention comprise substituted aminothiazoles derivatives having a disease-modifying action in the treatment of diseases associated with unregulated cell growth that include hepatocellular carcinoma, and infection with a hepatitis virus.

  本发明的药物组合物包括具有疾病调节作用的取代氨基噻唑衍生物，可用于治疗与细胞不规则生长有关的疾病，包括肝细胞癌和肝炎病毒感染。