{5-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-quinazolin-4-yl]-pyridin-3-yl}-(3,3,4-trimethyl-piperazin-1-yl)-methanone | 1431541-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: {5-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-quinazolin-4-yl]-pyridin-3-yl}-(3,3,4-trimethyl-piperazin-1-yl)-methanone
• 英文别名: {5-[6-(6-methoxy-5-trifluoromethylpyridin-3-yl)quinazolin-4-yl]pyridine-3-yl}-(3,3,4-trimethylpiperazin-1-yl)methanone；[5-[6-[6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]quinazolin-4-yl]pyridin-3-yl]-(3,3,4-trimethylpiperazin-1-yl)methanone；[5-[6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]quinazolin-4-yl]pyridin-3-yl]-(3,3,4-trimethylpiperazin-1-yl)methanone
• CAS: 1431541-72-8
• 化学式: C₂₈H₂₇F₃N₆O₂
• 分子量: 536.557
• InChiKey: HCCPPXGMHYPZAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  39
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  84.3
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Use of Inhibitors of the Activity or Function of PI3K
  申请人：NOVARTIS AG

  公开号：US20150342951A1

  公开（公告）日：2015-12-03

  The invention relates to new uses of PI3K inhibitors, wherein said inhibitors have an inhibitory action on the PI3K isoform delta for the treatment of immunopathology in a subject suffering from a disease or disorder selected from malaria, leishmaniasis, trypanosomiasis, toxoplasmosis and/or neurocysticercosis, via functional inhibition of TLR9 of the infected subject.

  该发明涉及PI3K抑制剂的新用途，其中所述抑制剂对PI3K同工酶δ具有抑制作用，用于治疗患有疟疾、利什曼病、锥虫病、弓形虫病和/或神经囊虫病等疾病或紊乱的受试者的免疫病理学，通过对感染受试者的TLR9的功能抑制。
• Quinazoline Derivatives
  申请人：Furet Pascal

  公开号：US20140249139A1

  公开（公告）日：2014-09-04

  The invention relates to substituted quinazoline derivative of the formula (I), wherein A, X 1 , X 2 , X 3 , X 4 and R 5 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

  本发明涉及公式（I）的取代喹唑啉衍生物，其中A、X1、X2、X3、X4和R5如描述中所定义。这种化合物适用于治疗由PI3K酶活性介导的疾病或疾患。
• US9949979B2
  申请人：——

  公开号：US9949979B2

  公开（公告）日：2018-04-24