(2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfonamido]propyl N-[3-(1H-imidazol-1-yl)propyl]-N-methylcarbamate | 290326-84-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfonamido]propyl N-[3-(1H-imidazol-1-yl)propyl]-N-methylcarbamate
• 英文别名: [(2R)-2-(2,5-dichloro-N-(4-chlorophenyl)sulfonylanilino)propyl] N-(3-imidazol-1-ylpropyl)-N-methylcarbamate
• CAS: 290326-84-0
• 化学式: C₂₃H₂₅Cl₃N₄O₄S
• 分子量: 559.901
• InChiKey: POIOTSUEZZWFIU-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  93.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  、 3-(1H-imidazol-1-yl)-N-methylpropan-1-amine 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 (2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfonamido]propyl N-[3-(1H-imidazol-1-yl)propyl]-N-methylcarbamate
  参考文献：
  名称：

  Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase

  摘要：

  The synthesis and gamma-secretase inhibition data for a series of carbamate-appended N-alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain A beta in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.102

文献信息

• US6967196B1
  申请人：——

  公开号：US6967196B1

  公开（公告）日：2005-11-22
• Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase
  作者：Carl P. Bergstrom、Charles P. Sloan、Wai-Yu Lau、David W. Smith、Ming Zheng、Steven B. Hansel、Craig T. Polson、Jason A. Corsa、Donna M. Barten、Kevin M. Felsenstein、Susan B. Roberts

  DOI：10.1016/j.bmcl.2007.11.102

  日期：2008.1

  The synthesis and gamma-secretase inhibition data for a series of carbamate-appended N-alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain A beta in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2. (c) 2007 Elsevier Ltd. All rights reserved.