15-[1-[4-[3-(14,16-Dioxo-1,4,7,10,13-pentaoxacyclohexadec-15-yl)indol-1-yl]butyl]indol-3-yl]-1,4,7,10,13-pentaoxacyclohexadecane-14,16-dione | 1006060-60-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: 15-[1-[4-[3-(14,16-Dioxo-1,4,7,10,13-pentaoxacyclohexadec-15-yl)indol-1-yl]butyl]indol-3-yl]-1,4,7,10,13-pentaoxacyclohexadecane-14,16-dione
• 英文别名: 15-[1-[4-[3-(14,16-dioxo-1,4,7,10,13-pentaoxacyclohexadec-15-yl)indol-1-yl]butyl]indol-3-yl]-1,4,7,10,13-pentaoxacyclohexadecane-14,16-dione
• CAS: 1006060-60-1
• 化学式: C₄₂H₅₂N₂O₁₄
• 分子量: 808.88
• InChiKey: VUVRAJWJEOHZFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  58
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  170
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  15-diazo-1,4,7,10,13-pentaoxacyclohexadecane-14,16-dione 、 1-(4-吲哚-1-基丁基)吲哚 在 dirhodium tetraacetate 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以42%的产率得到15-[1-[4-[3-(14,16-Dioxo-1,4,7,10,13-pentaoxacyclohexadec-15-yl)indol-1-yl]butyl]indol-3-yl]-1,4,7,10,13-pentaoxacyclohexadecane-14,16-dione
  参考文献：
  名称：

  Reactions of macrocyclic rhodium carbenoids: regioselective synthesis of indol-3-yl macrocyclic lactones and cryptands

  摘要：

  A wide variety of new macrocyclic diazocarbonyl compounds with various spacers was synthesized. Macrocyclic rhodium(H) carberioid insertion with various substituted indoles was performed to afford regioselectively, indol-3-yl macrocyclic di- or tetralactones (C3-alkylation). Double carberioid insertion was also performed to afford indolyl cryptand molecules. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.102

文献信息

• Reactions of macrocyclic rhodium carbenoids: regioselective synthesis of indol-3-yl macrocyclic lactones and cryptands
  作者：Sengodagounder Muthusamy、Boopathy Gnanaprakasam

  DOI：10.1016/j.tetlet.2007.11.102

  日期：2008.1

  A wide variety of new macrocyclic diazocarbonyl compounds with various spacers was synthesized. Macrocyclic rhodium(H) carberioid insertion with various substituted indoles was performed to afford regioselectively, indol-3-yl macrocyclic di- or tetralactones (C3-alkylation). Double carberioid insertion was also performed to afford indolyl cryptand molecules. (C) 2007 Elsevier Ltd. All rights reserved.