1-(3-bromophenyl)-N-chloromethanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-bromophenyl)-N-chloromethanamine
• 化学式: C₇H₇BrClN
• 分子量: 220.496
• InChiKey: NWSOLYLPAMCBIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(3-bromophenyl)-N-chloromethanamine 在 叔丁基过氧化氢 作用下， 以 水 、 乙腈 为溶剂， 反应 48.0h， 以67%的产率得到3-bromo-N-(3-bromobenzyl)benzamide
  参考文献：
  名称：

  Visible light-promoted self-coupling of N-chloramines at room temperature: A metal-free access to substituted amides

  摘要：

  An efficient protocol to synthesize substituted amides via self-coupling of N-chlorobenzylamines has been developed under visible light-promoted mild condition. Both the electron-deficient and electron-rich benzylamines undergo self-coupling very readily to produce the amide linkage under given reaction conditions.

  DOI：

  10.1080/00397911.2019.1678172

文献信息

• CaMKII INHIBITORS AND USES THEREOF
  申请人：ALLOSTEROS THERAPEUTICS, INC.

  公开号：US20160024078A1

  公开（公告）日：2016-01-28

  The present invention provides compounds useful as inhibitors of Ca 2+ /calmodulin-dependent protein kinase (CaMKII), compositions thereof, and methods of using the same.

  本发明提供了作为Ca2+/钙调蛋白激酶（CaMKII）抑制剂有用的化合物，其组成物和使用方法。
• [EN] CaMKII INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE CAMKII ET LEURS UTILISATIONS
  申请人：ALLOSTEROS THERAPEUTICS INC

  公开号：WO2014138212A1

  公开（公告）日：2014-09-12

  The present invention provides compounds useful as inhibitors of Ca2+/calmodulindependent protein kinase (CaMKII), compositions thereof, and methods of using the same. Cardiovascular disease remains the number one cause of death in developed countries. Furthermore, incidence of cardiovascular disease has increased dramatically in developing countries. Although cardiovascular disease usually affects older adults, the antecedents of cardiovascular disease, notably atherosclerosis, begin in early life, making primary prevention efforts necessary from childhood.