[(7aR)-9-methoxy-3-methyl-2,4,4a,5,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] benzoate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: [(7aR)-9-methoxy-3-methyl-2,4,4a,5,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] benzoate
• 化学式: C₂₅H₂₅NO₄
• 分子量: 403.5
• InChiKey: VPMRSLWWUXNYRY-CQMFLEKGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] PHARMACEUTICALLY ACCEPTABLE SALTS AND POLYMORPHIC FORMS OF HYDROCODONE BENZOIC ACID ENOL ESTER AND PROCESSES FOR MAKING SAME<br/>[FR] SELS PHARMACEUTIQUEMENT ACCEPTABLES ET FORMES POLYMORPHES DE L'ESTER ÉNOLIQUE DE L'ACIDE HYDROCODONE BENZOÏQUE ET LEURS PROCÉDÉS DE FABRICATION
  申请人：JOHNSON MATTHEY PLC

  公开号：WO2014138740A1

  公开（公告）日：2014-09-12

  Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs. Also provided are processes for the preparation of hydrocodone benzoic acid enol ester salts, and various polymorphs.

  包括羟考酮苯甲酸烯醇酯在内的组合物，形成包括羟考酮苯甲酸烯醇酯盐和各种多型体的新型前药。还提供了制备羟考酮苯甲酸烯醇酯盐和各种多型体的方法。
• Pharmaceutically acceptable salts and polymorphic forms of hydrocodone benzoic acid enol ester and processes for making same
  申请人：KemPharm, Inc.

  公开号：US10351574B2

  公开（公告）日：2019-07-16

  Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs. Also provided are processes for the preparation of hydrocodone benzoic acid enol ester salts, and various polymorphs.

  由氢可酮苯甲酸烯醇酯组成的组合物，可形成新型原药，包括氢可酮苯甲酸烯醇酯盐和各种多晶型物。此外，还提供了氢可酮苯甲酸烯醇酯盐和各种多晶型物的制备工艺。
• Pharmaceutically Acceptable Salts and Polymorphic Forms of Hydrocodone Benzoic Acid Enol Ester and Processes for Making Same
  申请人：JOHNSON MATTHEY PUBLIC LIMITED COMPANY

  公开号：US20160039837A1

  公开（公告）日：2016-02-11

  Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs. Also provided are processes for the preparation of hydrocodone benzoic acid enol ester salts, and various polymorphs.
• PHARMACEUTICALLY ACCEPTABLE SALTS AND POLYMORPHIC FORMS OF HYDROCODONE BENZOIC ACID ENOL ESTER AND PROCESSES FOR MAKING SAME
  申请人：KemPharm, Inc.

  公开号：US20190284197A1

  公开（公告）日：2019-09-19

  Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs. Also provided are processes for the preparation of hydrocodone benzoic acid enol ester salts, and various polymorphs.
• US9815844B2
  申请人：——

  公开号：US9815844B2

  公开（公告）日：2017-11-14