(4-bromo-3-fluorophenyl)(2,2-diethoxyethyl)sulfane

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (4-bromo-3-fluorophenyl)(2,2-diethoxyethyl)sulfane
• 英文别名: (4-Bromo-3-fluorophenyl)(2,2-diethoxyethyl)sulfane；1-bromo-4-(2,2-diethoxyethylsulfanyl)-2-fluorobenzene
• 化学式: C₁₂H₁₆BrFO₂S
• 分子量: 323.226
• InChiKey: UHJBPAQSOYXUMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4-bromo-3-fluorophenyl)(2,2-diethoxyethyl)sulfane 在 磷酸 作用下， 以 甲苯 为溶剂， 以46.6 %的产率得到5-bromo-6-fluorobenzo[b]thiophene
  参考文献：
  名称：

  ANILINO-PYRAZOLE DERIVATIVES, COMPOSITIONS AND METHODS THEREOF

  摘要：

  The invention provides novel anilino-pyrazole derivatives as a cyclin-dependent kinase 2 (CDK2) inhibitors. The invention also provides pharmaceutical compositions comprising the compounds and methods thereof for treating various conditions, diseases and disorders associated with or related to CDK2 activities, or associated with abnormal cell growth, such as tumor growth and cancer.

  公开号：

  WO2023244710A1
• 作为产物：
  描述：

  3-氟-4-溴苯磺酰氯 在 potassium carbonate 、 三苯基膦 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 3.5h， 生成 (4-bromo-3-fluorophenyl)(2,2-diethoxyethyl)sulfane
  参考文献：
  名称：

  ANILINO-PYRAZOLE DERIVATIVES, COMPOSITIONS AND METHODS THEREOF

  摘要：

  The invention provides novel anilino-pyrazole derivatives as a cyclin-dependent kinase 2 (CDK2) inhibitors. The invention also provides pharmaceutical compositions comprising the compounds and methods thereof for treating various conditions, diseases and disorders associated with or related to CDK2 activities, or associated with abnormal cell growth, such as tumor growth and cancer.

  公开号：

  WO2023244710A1

文献信息

• 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES
  申请人：Dow AgroSciences, LLC

  公开号：US20150126372A1

  公开（公告）日：2015-05-07

  4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.

  4-氨基-6-(杂环)吡啶甲酸及其衍生物；6-氨基-2-(杂环)嘧啶-4-羧酸酯及其衍生物；以及将其作为除草剂的方法。
• 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
  申请人：Dow AgroSciences, LLC

  公开号：US09278985B2

  公开（公告）日：2016-03-08

  4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.

  4-氨基-6-(杂环)吡啶甲酸及其衍生物；6-氨基-2-(杂环)嘧啶-4-羧酸盐及其衍生物；以及将其用作除草剂的方法。
• US2014/274695
  申请人：——

  公开号：——

  公开（公告）日：——
• US20140274695A1
  申请人：——

  公开号：——

  公开（公告）日：——
• 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-2(HETEROCYCLIC) PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES
  申请人：Dow AgroSciences LLC

  公开号：EP2970187A1

  公开（公告）日：2016-01-20