6-amino-5-hydroxy-1H-pyrimidin-2-one;5-hydroxy-1H-pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-amino-5-hydroxy-1H-pyrimidin-2-one;5-hydroxy-1H-pyrimidine-2,4-dione
• 化学式: C8H9N5O5
• 分子量: 255.19
• InChiKey: GPMCZAFFPQMMDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.17
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• METHODS FOR AMPLIFICATION AND SEQUENCING USING THERMOSTABLE TTHPRIMPOL
  申请人：SYGNIS Biotech S.L.U.

  公开号：EP2971080A1

  公开（公告）日：2016-01-20
• [EN] METHODS FOR AMPLIFICATION AND SEQUENCING USING THERMOSTABLE TTHPRIMPOL<br/>[FR] PROCÉDÉS D'AMPLIFICATION ET DE SÉQUENÇAGE À L'AIDE DE TTHPRIMPOL THERMIQUEMENT STABLE
  申请人：SYGNIS BIOTECH S L U

  公开号：WO2014140309A1

  公开（公告）日：2014-09-18

  The present invention is directed to methods for replicating, amplifying, and sequencing of nucleic acids using the thermostable, bifunctional replicase "TthPrimPol" from Thermus thermophilus HB27. The TthPrimPol enzyme is extremely tolerant to alterations of the nucleotides of the template nucleic acid. Therefore, in one aspect the invention discloses methods for replicating, amplifying and sequencing of damaged polynucleotide templates.