(1S,10R,11R,14R)-4-methoxy-18-methyl-6-oxa-18-azapentacyclo[8.5.3.01,11.02,8.05,7]octadeca-2,4,7,12-tetraen-14-ol

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (1S,10R,11R,14R)-4-methoxy-18-methyl-6-oxa-18-azapentacyclo[8.5.3.01,11.02,8.05,7]octadeca-2,4,7,12-tetraen-14-ol
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.4
• InChiKey: WBOZFHKYSMWVDM-XFFUPTALSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ABUSE RESISTANT CAPSULE
  申请人：R.P. Scherer Technologies, LLC

  公开号：EP2968129A1

  公开（公告）日：2016-01-20
• [EN] ABUSE RESISTANT CAPSULE<br/>[FR] CAPSULE RÉSISTANTE AUX ABUS
  申请人：WENGNER SIMONE

  公开号：WO2014140231A1

  公开（公告）日：2014-09-18

  The present invention is directed to an immediate release and extended release capsule or capsule fill which mitigates the abuse of abuse-susceptible active pharmaceutical ingredients by direct intravenous injection. The fill comprises a parenteral abuse resistant liquid formulation which when mixed with water and heated, results in a turbid, viscous or bubbling mixture that is not injectable with a standard insulin syringe. The abuse-susceptible active pharmaceutical ingredient is selected from the group consisting of opiates, opioids, tranquillizers, stimulants and narcotics.
• [EN] METHODS AND COMPOSITIONS FOR SELF-REGULATED RELEASE OF ACTIVE PHARMACEUTICAL INGREDIENT<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA LIBÉRATION AUTO-RÉGULÉE D'UN INGRÉDIENT PHARMACEUTIQUE ACTIF
  申请人：ACURA PHARMACEUTICALS INC

  公开号：WO2017040607A1

  公开（公告）日：2017-03-09

  An abuse deterrent pharmaceutical composition including an acid soluble salt of a pharmaceutically active ingredient and a buffering ingredient; wherein the acid soluble salt of the pharmaceutically active ingredient and the buffering ingredient retard release of the pharmaceutically active ingredient when the composition is ingested in excess of an intended dosage.