(5-Methyl-2,4-dioxo-3-propylpyrimidin-1-yl)oxymethylphosphonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (5-Methyl-2,4-dioxo-3-propylpyrimidin-1-yl)oxymethylphosphonic acid
• 英文别名: (5-methyl-2,4-dioxo-3-propylpyrimidin-1-yl)oxymethylphosphonic acid
• 化学式: C₉H₁₅N₂O₆P
• 分子量: 278.2
• InChiKey: ARTYYWPYFUOMSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
  申请人：The Regents of the University of California

  公开号：US20170002033A1

  公开（公告）日：2017-01-05

  The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

  本公开涉及用于治疗病毒性疾病和癌症的组合物和方法，其中包括脂溶性抗病毒和抗癌无环核苷酸膦酸二酯，其制备方法以及使用这些化合物治疗病毒性疾病和癌症的方法。
• Acyclic nucleoside phosphonate diesters
  申请人：The Regents of the University of California

  公开号：US10076532B2

  公开（公告）日：2018-09-18

  The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

  本公开主要涉及治疗病毒性疾病和癌症的组合物和方法。本发明公开了亲脂性抗病毒和抗癌无环核苷膦酸二酯、其制备方法以及使用该化合物治疗病毒性疾病和癌症的方法。
• Acyclic Nucleoside Phosphonate Diesters
  申请人：The Regents of the University of California

  公开号：US20180360859A1

  公开（公告）日：2018-12-20

  The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
• US9156867B2
  申请人：——

  公开号：US9156867B2

  公开（公告）日：2015-10-13
• US9387217B2
  申请人：——

  公开号：US9387217B2

  公开（公告）日：2016-07-12